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Volume 71
Issue 3
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Adamantam Derivatives, Part 111* : Synthesis of Some Aminoadamantanes as Novel Antitumor Agents

by
M. A. El-Sherbeny
1,*,
K. M. Youssef
2 and
M. A. Mahran
3
1
Department of Medicinal Chemistry, College Of Pharmacy, University of Mansoura, Mansoura 35516, Egypt
2
Department of Medicinal Chemistry, College Of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia
3
Department of Pharmaceutical Chemistry, School of Pharmacy, Universrty of Alexandria, Alexandria 21521, Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2003, 71(3), 195-209; https://doi.org/10.3797/scipharm.aut-03-19
Submission received: 8 January 2003 / Revised: 28 April 2003 / Accepted: 28 April 2003 / Published: 15 July 2003
Versions Notes

Abstract

New series of 1-(1-adamantyl)semicarbazide 3a, 1-(1-adamantyl)4(4-subsMuted pheny1)semicarbazides 3b-e, 1-(1-adamantyl)-3-(subsMuted aminosulfonyl)ureas 5a-g, 1-(1-adamantyl)-4-(1-adamantylamino-methylene)-semicarbazide 7, 1-(1-adamantyl)-4-(1-adamantylcarbonylmethyl)semicarbazide 8, 1-(Iadamantyl)-4-acylsemicarbazides Sad and 1-(1-adamantyl)-4-(1-adamantylaminocarbonyl) thiosemicarbazide 10 have been synthesized and tested for their anMumor activity. Among them, compounds 3a, 5a, 9a. and 9d exhibited a broad spectrum antitumor activity with full panel (MG-MID) median growth inhibition (GI50) of 1 0.5, 12.0, 6.8 and 5.5 μM respectively. In addition, compounds 3a, 3c, and 5d proved to be of moderate selectivity toward leukemia cell lines wrth ratios of 3.0, 3.9 and 4.0 respectively. Moreover, compounds 5a and 5g showed moderate selectivrty toward melanoma cell lines with ratios of 3.6 and 4.4 respectively. The detailed synthesis, specroscopic and biological data are reported.
Keywords: Adamantyl Semicarbazides; Adamantyl Sulfonylureas and, Adamantyl Thiosemicarbazide; Synthesis; Antitumor Evaluation Adamantyl Semicarbazides; Adamantyl Sulfonylureas and, Adamantyl Thiosemicarbazide; Synthesis; Antitumor Evaluation

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MDPI and ACS Style

El-Sherbeny, M.A.; Youssef, K.M.; Mahran, M.A. Adamantam Derivatives, Part 111* : Synthesis of Some Aminoadamantanes as Novel Antitumor Agents. Sci. Pharm. 2003, 71, 195-209. https://doi.org/10.3797/scipharm.aut-03-19

AMA Style

El-Sherbeny MA, Youssef KM, Mahran MA. Adamantam Derivatives, Part 111* : Synthesis of Some Aminoadamantanes as Novel Antitumor Agents. Scientia Pharmaceutica. 2003; 71(3):195-209. https://doi.org/10.3797/scipharm.aut-03-19

Chicago/Turabian Style

El-Sherbeny, M. A., K. M. Youssef, and M. A. Mahran. 2003. "Adamantam Derivatives, Part 111* : Synthesis of Some Aminoadamantanes as Novel Antitumor Agents" Scientia Pharmaceutica 71, no. 3: 195-209. https://doi.org/10.3797/scipharm.aut-03-19

APA Style

El-Sherbeny, M. A., Youssef, K. M., & Mahran, M. A. (2003). Adamantam Derivatives, Part 111* : Synthesis of Some Aminoadamantanes as Novel Antitumor Agents. Scientia Pharmaceutica, 71(3), 195-209. https://doi.org/10.3797/scipharm.aut-03-19

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