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Sci. Pharm.
Volume 69
Issue 1
10.3797/scipharm.aut-01-04
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Article

ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF 2-PHENYL (6, 8-DISUBSTITUTED 3,4-DIHYDRO-4-OXOQUINAZLIN-3-YCL) ACETO ACETAMIDES AND THEIR ß (4-SUBSTITUTED PHENYL) AZO ANALOGS

by
N. Gopa
1,*,
E. Porchezhian
2 and
G.V.S. Rama Sarma
2
1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jarnia Hamdard, Hamdard Nagar, New Delhi-62, India
2
Department of Pharmaceutical Chemistry, Centre for Advanced Research, J.S.S. College of Pharmacy, Ooty, Tamil Nadu-643 00 1, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2001, 69(1), 27-32; https://doi.org/10.3797/scipharm.aut-01-04
Submission received: 4 April 2000 / Accepted: 16 January 2001 / Published: 30 March 2001
Versions Notes

Abstract

2-phenyl-(3,4-dihydro-4-oxoquinazolin-3-yalc)e to acetamides (1&2) and their B-(4-substituted phenyl) azo derivatives (3-10) were evaluated for their analgesic and antiinflammatory activities. The bromophenyl azo derivative (4) showed significant activity as comparable to standard drugs viz pentazocine, aspirin and other compounds exhibited moderate activities. All the synthesized compounds were tested for their toxicity have not shown any abnormality up to 1500 mg/kg Body weight in experimental animals.
Keywords: quinazolinones; azoaceto acetamides; anti-inflammatory; analgesic quinazolinones; azoaceto acetamides; anti-inflammatory; analgesic

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MDPI and ACS Style

Gopa, N.; Porchezhian, E.; Sarma, G.V.S.R. ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF 2-PHENYL (6, 8-DISUBSTITUTED 3,4-DIHYDRO-4-OXOQUINAZLIN-3-YCL) ACETO ACETAMIDES AND THEIR ß (4-SUBSTITUTED PHENYL) AZO ANALOGS. Sci. Pharm. 2001, 69, 27-32. https://doi.org/10.3797/scipharm.aut-01-04

AMA Style

Gopa N, Porchezhian E, Sarma GVSR. ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF 2-PHENYL (6, 8-DISUBSTITUTED 3,4-DIHYDRO-4-OXOQUINAZLIN-3-YCL) ACETO ACETAMIDES AND THEIR ß (4-SUBSTITUTED PHENYL) AZO ANALOGS. Scientia Pharmaceutica. 2001; 69(1):27-32. https://doi.org/10.3797/scipharm.aut-01-04

Chicago/Turabian Style

Gopa, N., E. Porchezhian, and G.V.S. Rama Sarma. 2001. "ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF 2-PHENYL (6, 8-DISUBSTITUTED 3,4-DIHYDRO-4-OXOQUINAZLIN-3-YCL) ACETO ACETAMIDES AND THEIR ß (4-SUBSTITUTED PHENYL) AZO ANALOGS" Scientia Pharmaceutica 69, no. 1: 27-32. https://doi.org/10.3797/scipharm.aut-01-04

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