Next Article in Journal
Die Emerson-Reaktion des Salbutamols
Previous Article in Journal
3D-QSAR STUDY OF NEW ACETYL-COA:CHOLESTEROL O-ACYL TRANSFERASE (ACAT) INHIBITORS
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle

Zur Synthese von ionenkanalblockierenden Substanzen mit Thieno[2,3-b][1,4]thiazin-, 1,4-Benzoxazin und 1,4-Benzothiazin-Grundgerüst

Institut für Pharmazeutische Chemie der Universität Wien, Althanstraße 14, A-1090 Wien, Österreich
*
Author to whom correspondence should be addressed.
$
Herrn o. Univ.-Prof. Dr. W. Kubelka mit den besten Wünschen zum 65. Geburtstag gewidmet
Sci. Pharm. 2000, 68(1), 75-85; https://doi.org/10.3797/scipharm.aut-00-07
Received: 31 January 2000 / Revised: 3 March 2000 / Accepted: 3 March 2000 / Published: 10 March 2000
The syntheses of the thieno[2,3-b)[1,4]thiazine derivatives 8 and 9 are described. Reaction of compound 4 with different acyl halides followed by substitution with various ethanamines gave the products 8 and 9. The new 3,4-dihydro-2H-1,4-benzoxazine derivatives 14, 16, 18 and 3,4-dihydro-2H-1,4-benzothiazine derivatives 15 and 17 with an urea moiety have been synthesized. Substitution of 10 respectively 11 with 4-nitrophenyl chloroformate gave the required reactivity for substitution with diamines. Structural modifications of the amino side chain were carried out.
Keywords: Thieno[2,3-b][1, 4]thiazines; 1,4-Benzoxazines; 1,4-Benzothiazines; Ion Channel Antagonistic Activity Thieno[2,3-b][1, 4]thiazines; 1,4-Benzoxazines; 1,4-Benzothiazines; Ion Channel Antagonistic Activity
MDPI and ACS Style

Schreder, M.E.; Erker, T. Zur Synthese von ionenkanalblockierenden Substanzen mit Thieno[2,3-b][1,4]thiazin-, 1,4-Benzoxazin und 1,4-Benzothiazin-Grundgerüst. Sci. Pharm. 2000, 68, 75-85.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop