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Open AccessArticle

Severity of Anaemia Has Corresponding Effects on Coagulation Parameters of Sickle Cell Disease Patients

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Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143 Accra, Ghana
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Department of Medical Laboratory Sciences, School of Allied Health Sciences, Narh-Bita College, P.O. Box Co1061 Tema, Ghana
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Author to whom correspondence should be addressed.
Diseases 2019, 7(4), 59; https://doi.org/10.3390/diseases7040059
Received: 31 July 2019 / Revised: 18 October 2019 / Accepted: 18 October 2019 / Published: 17 December 2019
Sickle cell disease (SCD) is an inherited condition characterized by chronic haemolytic anaemia. SCD is associated with moderate to severe anaemia, hypercoagulable state and inconsistent platelet count and function. However, studies have yielded conflicting results with regards to the effect of anaemia on coagulation in SCD. The purpose of this study was to determine the effect of anaemia severity on selected coagulation parameters of SCD patients. Four millilitres of venous blood samples were taken from the participants (SCD and non-SCD patients) and used for analysis of full blood count and coagulation parameters. Data was analysed using SPSS version-16. From the results, it was seen that individuals with SCD had a prolonged mean PT, APTT and high platelet count compared to the controls. There was also significant difference in the mean PT (p = 0.039), APTT (p = 0.041) and platelet count (p = 0.010) in HbSS participants with severe anaemia. Mean APTT also showed significant difference (p = 0.044) with severe anaemia in HbSC participants. It can be concluded that SCD patients have prolonged PT, APTT and increased platelet count which might predispose them to bleeding episodes and thrombocytosis. Significant difference was also seen between severity of anaemia and mean PT, APTT and platelet count in HbSS individuals. View Full-Text
Keywords: haemoglobin; sickle cell disease; platelets; prothrombin; coagulation; anaemia; antithrombin; haemolysis haemoglobin; sickle cell disease; platelets; prothrombin; coagulation; anaemia; antithrombin; haemolysis
MDPI and ACS Style

Antwi-Baffour, S.; Kyeremeh, R.; Annison, L. Severity of Anaemia Has Corresponding Effects on Coagulation Parameters of Sickle Cell Disease Patients. Diseases 2019, 7, 59.

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