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Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases

1
Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan
2
Japan Community Health care Organization Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi, Chiba 273-8556, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Carlo Catassi
Diseases 2016, 4(4), 38; https://doi.org/10.3390/diseases4040038
Received: 2 November 2016 / Revised: 7 December 2016 / Accepted: 9 December 2016 / Published: 14 December 2016
(This article belongs to the Section Gastroenterology)
Background: Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA(+)-M2BP) is a novel non-invasive marker of liver fibrosis. The goal of the study was to investigate whether the novel serum biomarker WFA(+)-M2BP or other non-invasive markers are useful for the prediction of liver fibrosis in patients with nonalcoholic steatohepatitis (NASH), autoimmune hepatitis (AIH), and primary biliary cholangitis (PBC). Methods: We examined a significant correlation between serum WFA(+)-M2BP levels and histological staging of fibrosis in several chronic liver diseases, such as NASH, AIH, and PBC. Results: WFA(+)-M2BP could not predict hepatic fibrosis in these patients. We also showed that the level of platelet counts is a useful predictor of hepatic fibrosis progression in patients with NASH, AIH, and PBC. There was a significant correlation between staging of fibrosis and grading of activity in the liver in all groups except for AIH patients. Conclusion: Platelet counts can predict hepatic fibrosis in patients with NASH, AIH, or PBC. Clinicians should pay attention to the grading of liver activity in the use of WFA(+)-M2BP. View Full-Text
Keywords: autoimmune hepatitis; nonalcoholic steatohepatitis; primary biliary cholangitis; WFA(+)-M2BP; M2BPGi autoimmune hepatitis; nonalcoholic steatohepatitis; primary biliary cholangitis; WFA(+)-M2BP; M2BPGi
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Haga, Y.; Kanda, T.; Sasaki, R.; Nakamura, M.; Takahashi, K.; Wu, S.; Yasui, S.; Arai, M.; Nakamoto, S.; Yokosuka, O. Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases. Diseases 2016, 4, 38.

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