Distribution and Evolutionary History of the Mobile Genetic Element s2m in Coronaviruses
by
Torstein Tengs 1,* and Christine M. Jonassen 2
Torstein Tengs 1,* and Christine M. Jonassen 2
1
Norwegian Veterinary Institute, Ullevaalsveien 68, 0454 Oslo, Norway
2
Centre for Laboratory Medicine, Østfold Hospital Trust, Kalnesveien 300, 1714 Grålum, Norway
*
Author to whom correspondence should be addressed.
Academic Editor: Ding Xiang Liu
Diseases 2016, 4(3), 27; https://doi.org/10.3390/diseases4030027
Received: 31 May 2016 / Revised: 20 July 2016 / Accepted: 25 July 2016 / Published: 28 July 2016
(This article belongs to the Special Issue Advances in Coronaviruses Research: Important Emerging Human Pathogens)
The mobile genetic element s2m has been described in several families of single-stranded RNA viruses. The function remains elusive, but an increasing number of s2m-containing sequences are being deposited in publicly available databases. Currently, more than 700 coronavirus sequences containing s2m can be found in GenBank, including the severe acute respiratory syndrome (SARS) coronavirus genome. This is an updated review of the pattern of s2m in coronaviruses, the possible functional implications and the evolutionary history.
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Keywords:
s2m; coronavirus; secondary structure; mobile genetic element
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Tengs, T.; Jonassen, C.M. Distribution and Evolutionary History of the Mobile Genetic Element s2m in Coronaviruses. Diseases 2016, 4, 27.
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