Next Article in Journal / Special Issue
The Role of Glucosinolate Hydrolysis Products from Brassica Vegetable Consumption in Inducing Antioxidant Activity and Reducing Cancer Incidence
Previous Article in Journal
Trimester-Specific Reference Intervals of Thyroid Function Testing in Pregnant Women from Basrah, Iraq Using Electrochemiluminescent Immunoassay
Previous Article in Special Issue
Effect of Dietary Bioactive Compounds on Mitochondrial and Metabolic Flexibility
Article Menu

Export Article

Open AccessReview
Diseases 2016, 4(2), 21;

Targeting MicroRNA in Cancer Using Plant-Based Proanthocyanidins

Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus, North Carolina Agricultural and Technical State University, Kannapolis, NC 28081, USA
School of Nutrition & Food Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 29 February 2016 / Revised: 11 April 2016 / Accepted: 22 April 2016 / Published: 28 April 2016
Full-Text   |   PDF [1353 KB, uploaded 28 April 2016]   |  


Proanthocyanidins are oligomeric flavonoids found in plant sources, most notably in apples, cinnamon, grape skin and cocoa beans. They have been also found in substantial amounts in cranberry, black currant, green tea, black tea and peanut skins. These compounds have been recently investigated for their health benefits. Proanthocyanidins have been demonstrated to have positive effects on various metabolic disorders such as inflammation, obesity, diabetes and insulin resistance. Another upcoming area of research that has gained widespread interest is microRNA (miRNA)-based anticancer therapies. MicroRNAs are short non-coding RNA segments, which plays a crucial role in RNA silencing and post-transcriptional regulation of gene expression. Currently, miRNA based anticancer therapies are being investigated either alone or in combination with current treatment methods. In this review, we summarize the current knowledge and investigate the potential of naturally occurring proanthocyanidins in modulating miRNA expression. We will also assess the strategies and challenges of using this approach as potential cancer therapeutics. View Full-Text
Keywords: proanthocyanidins; microRNA; cancer; polyphenols proanthocyanidins; microRNA; cancer; polyphenols

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Bansode, R.R.; Khatiwada, J.R.; Losso, J.N.; Williams, L.L. Targeting MicroRNA in Cancer Using Plant-Based Proanthocyanidins. Diseases 2016, 4, 21.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Diseases EISSN 2079-9721 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top