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Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome

Department of Pediatrics, Division of Endocrinology, University of Florida College of Medicine, 32607 Gainesville, FL, USA
Department of Medicine, University of Alabama at Birmingham, 35294 Birmingham, AL, USA
Foundation for Prader-Willi Research, 91789 Walnut, CA, USA
Prader-Willi syndrome Association USA, 34238 Sarasota, FL, USA
Author to whom correspondence should be addressed.
Academic Editor: Danny Camfferman
Diseases 2015, 3(2), 78-85;
Received: 31 March 2015 / Revised: 20 May 2015 / Accepted: 21 May 2015 / Published: 3 June 2015
(This article belongs to the Special Issue Prader-Willi Syndrome)
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by the absence of paternally expressed, imprinted genes on chromosome 15q11-13. Individuals with PWS characteristically have poor feeding and lack of appetite in infancy, followed by the development of weight gain and then uncontrolled appetite and lack of satiety, sometime after the age of two. The overwhelming drive to eat is coupled with reduced energy expenditure and decreased caloric requirements, thus, individuals with PWS will become severely obese unless their food intake is strictly controlled. The mechanisms underlying hyperphagia in PWS remain incompletely understood, and to date no drugs have proven effective in controlling appetite. However, clinical trials have started for several medications, which may provide therapeutic options for those with PWS. These medication trials may also provide insight into potential treatments for obesity in the general population. Ideally, these treatments will help alleviate the complex metabolic issues that are part of this syndrome. View Full-Text
Keywords: Prader-Willi syndrome; hyperphagia; drug trials; obesity Prader-Willi syndrome; hyperphagia; drug trials; obesity
MDPI and ACS Style

Miller, J.L.; Strong, T.V.; Heinemann, J. Medication Trials for Hyperphagia and Food-Related Behaviors in Prader–Willi Syndrome. Diseases 2015, 3, 78-85.

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