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Open AccessReview

Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies

Nottingham Digestive Diseases Biomedical Research Unit, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK
Academic Editor: Marina de Bernard
Diseases 2015, 3(2), 34-55; https://doi.org/10.3390/diseases3020034
Received: 11 December 2014 / Revised: 3 March 2015 / Accepted: 5 March 2015 / Published: 27 March 2015
(This article belongs to the Special Issue Helicobacter Pylori Infection)
A large number of studies link H. pylori infection with a reduced risk of developing extra-gastric conditions such as allergy, asthma, inflammatory bowel disease, coeliac disease and multiple sclerosis. The strength of the evidence for these protective associations is quite variable, and published studies often do not agree. This review article discusses some of the reasons for these discrepancies, and the difficulties faced when designing studies. Examples of some protective disease associations are described in detail, where the evidence is most abundant and thought to be more reliable. The most convincing of these are supported by published mechanistic data, for example with animal models, or incidence of disease exacerbation in humans following H. pylori eradication. Although controversial, this field is very important as the prevalence of H. pylori is decreasing throughout the world whilst many chronic diseases are becoming more common. These trends are likely to continue in the future, therefore it is important that we fully understand if and how H. pylori confers protection. View Full-Text
Keywords: Helicobacter pylori; extra-gastric manifestations; GORD; asthma; allergy; autoimmuity Helicobacter pylori; extra-gastric manifestations; GORD; asthma; allergy; autoimmuity
MDPI and ACS Style

Robinson, K. Helicobacter pylori-Mediated Protection against Extra-Gastric Immune and Inflammatory Disorders: The Evidence and Controversies. Diseases 2015, 3, 34-55.

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