Next Article in Journal
Prognostication in Pulmonary Arterial Hypertension with Submaximal Exercise Testing
Next Article in Special Issue
Kid-Short Marfan Score (Kid-SMS) Is a Useful Diagnostic Tool for Stratifying the Pre-Test Probability of Marfan Syndrome in Childhood
Previous Article in Journal
Impact of Aging on Liver Histological Findings of Autoimmune Liver Diseases
Previous Article in Special Issue
Facial and Ocular Features of Marfan Syndrome
Open AccessArticle

Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root

by Tom Treasure 1,* and John Pepper 2
1
Clinical Operational Research Unit, Department of Mathematics, University College London, Gower Street, London WC1E 6BT, UK
2
National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit (BRU), Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Varga
Diseases 2015, 3(1), 2-14; https://doi.org/10.3390/diseases3010002
Received: 16 October 2014 / Accepted: 4 January 2015 / Published: 15 January 2015
(This article belongs to the Special Issue Marfan Syndrome: Recognition, Diagnosis and Managements)
Personalised external aortic support was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. After putting together a research and development team, and finding a surgeon to take on the challenge to join him in this innovative approach, he was central to the manufacture of the device, custom made for his own aorta. He was the patient for the ‘first in man’ operation in 2004. Ten years later he is well and 45 other people have had their own personalised device implanted. In this account, the stepwise record of proof of principle, comparative quantification of the surgical and perioperative requirements, 10 years of results, and development and research plans for the future are presented. View Full-Text
Keywords: Marfan syndrome; aortic root aneurysm; surgery Marfan syndrome; aortic root aneurysm; surgery
Show Figures

Figure 1

MDPI and ACS Style

Treasure, T.; Pepper, J. Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root. Diseases 2015, 3, 2-14.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop