Next Article in Journal
Collaborative Consumption: Towards a Resource-Saving Consumption Culture
Next Article in Special Issue
European Hazelnut and Almond Genetic Resources: Safeguard and Traditional Uses
Previous Article in Journal
Identifying Key Sectors and Measures for a Transition towards a Low Resource Economy
Previous Article in Special Issue
Access to and Benefit Sharing of Plant Genetic Resources: Novel Field Experiences to Inform Policy
Open AccessReview

Recent Research Progress and Potential Uses of the Amphibian Xenopus as a Biomedical and Immunological Model System

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Author to whom correspondence should be addressed.
Resources 2013, 2(3), 167-183;
Received: 27 May 2013 / Revised: 30 June 2013 / Accepted: 6 July 2013 / Published: 18 July 2013
(This article belongs to the Special Issue Equitable and Sustainable Use of Genetic Resources)
The amphibian Xenopus has long been a comparative model system of choice for a number of different biological research areas, including immunology. Specifically, the evolutionary distance between amphibians and mammals, including humans, allows for the study of both species-specific adaptations, as well as conserved features of the immune system. Furthermore, the Xenopus genus includes species with multiple levels of polyploidy, thereby providing a unique model to study whole genome duplication and its effects thereof on individual genes. To better exploit this amphibian model, the development and innovative applications of novel research tools have been a priority. In this regard, recent advances in adapting the transgenesis approach to Xenopus have allowed for in vivo studies of the impact of loss and gain of function of specific genes at the level of the whole organism, further enhancing the potential uses of Xenopus as an important biomedical model system. This review highlights some of the major uses and applications of the Xenopus model. View Full-Text
Keywords: Xenopus; biomedical model; transgenesis Xenopus; biomedical model; transgenesis
Show Figures

Graphical abstract

MDPI and ACS Style

Edholm, E.-S.; Robert, J. Recent Research Progress and Potential Uses of the Amphibian Xenopus as a Biomedical and Immunological Model System. Resources 2013, 2, 167-183.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Search more from Scilit
Back to TopTop