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Glycerophosphate/Acylglycerophosphate Acyltransferases

Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan
Author to whom correspondence should be addressed.
Biology 2014, 3(4), 801-830;
Received: 12 September 2014 / Revised: 2 November 2014 / Accepted: 5 November 2014 / Published: 19 November 2014
(This article belongs to the Special Issue Lipid Metabolism)
PDF [445 KB, uploaded 19 November 2014]


Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesis of TAG and obesity-related diseases were revealed through the identification of causative genes of these diseases or analyses of genetically manipulated animals. Recent studies have suggested that some isoforms of GPAT/AGPAT family enzymes are involved in the fatty acid remodeling of phospholipids. The enzymology of GPAT/AGPAT and their physiological/ pathological roles in the metabolism of glycerolipids have been described and discussed in this review. View Full-Text
Keywords: acyltransferase; acyl-CoA; triacylglycerol; phospholipid; GPAT; AGPAT acyltransferase; acyl-CoA; triacylglycerol; phospholipid; GPAT; AGPAT

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Yamashita, A.; Hayashi, Y.; Matsumoto, N.; Nemoto-Sasaki, Y.; Oka, S.; Tanikawa, T.; Sugiura, T. Glycerophosphate/Acylglycerophosphate Acyltransferases. Biology 2014, 3, 801-830.

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