AbstractAcyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesis of TAG and obesity-related diseases were revealed through the identification of causative genes of these diseases or analyses of genetically manipulated animals. Recent studies have suggested that some isoforms of GPAT/AGPAT family enzymes are involved in the fatty acid remodeling of phospholipids. The enzymology of GPAT/AGPAT and their physiological/ pathological roles in the metabolism of glycerolipids have been described and discussed in this review. View Full-Text
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Yamashita, A.; Hayashi, Y.; Matsumoto, N.; Nemoto-Sasaki, Y.; Oka, S.; Tanikawa, T.; Sugiura, T. Glycerophosphate/Acylglycerophosphate Acyltransferases. Biology 2014, 3, 801-830.
Yamashita A, Hayashi Y, Matsumoto N, Nemoto-Sasaki Y, Oka S, Tanikawa T, Sugiura T. Glycerophosphate/Acylglycerophosphate Acyltransferases. Biology. 2014; 3(4):801-830.Chicago/Turabian Style
Yamashita, Atsushi; Hayashi, Yasuhiro; Matsumoto, Naoki; Nemoto-Sasaki, Yoko; Oka, Saori; Tanikawa, Takashi; Sugiura, Takayuki. 2014. "Glycerophosphate/Acylglycerophosphate Acyltransferases." Biology 3, no. 4: 801-830.