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An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA)

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01, Singapore 138669, Singapore
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Christopher C. Butler
Antibiotics 2015, 4(4), 424-434; https://doi.org/10.3390/antibiotics4040424
Received: 25 July 2015 / Revised: 15 September 2015 / Accepted: 22 September 2015 / Published: 9 October 2015
The lack of new antibacterial drugs entering the market and their misuse have resulted in the emergence of drug-resistant bacteria, posing a major health crisis worldwide. In particular, meticillin-resistant Staphylococcus aureus (MRSA), a pathogen responsible for numerous human infections, has become endemic in hospitals worldwide. Drug repurposing, the finding of new therapeutic indications for approved drugs, is deemed a plausible solution to accelerate drug discovery and development in this area. Towards this end, we screened 1163 drugs approved by the Food and Drug Administration (FDA) for bioactivities against MRSA in a 10 μM single-point assay. After excluding known antibiotics and antiseptics, six compounds were identified and their MICs were determined against a panel of clinical MRSA strains. A toxicity assay using human keratinocytes was also conducted to gauge their potential for repurposing as topical agents for treating MRSA skin infections. View Full-Text
Keywords: drug library screen; drug repurposing; drug repositioning; MRSA drug library screen; drug repurposing; drug repositioning; MRSA
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MDPI and ACS Style

Lau, Q.Y.; Tan, Y.Y.F.; Goh, V.C.Y.; Lee, D.J.Q.; Ng, F.M.; Ong, E.H.Q.; Hill, J.; Chia, C.S.B. An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA). Antibiotics 2015, 4, 424-434. https://doi.org/10.3390/antibiotics4040424

AMA Style

Lau QY, Tan YYF, Goh VCY, Lee DJQ, Ng FM, Ong EHQ, Hill J, Chia CSB. An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA). Antibiotics. 2015; 4(4):424-434. https://doi.org/10.3390/antibiotics4040424

Chicago/Turabian Style

Lau, Qiu Y., Yoke Y.F. Tan, Vanessa C.Y. Goh, David J.Q. Lee, Fui M. Ng, Esther H.Q. Ong, Jeffrey Hill, and Cheng S.B. Chia 2015. "An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA)" Antibiotics 4, no. 4: 424-434. https://doi.org/10.3390/antibiotics4040424

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