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Drug Resistance Mechanisms in Mycobacterium tuberculosis

Laboratory of Microbiology, Department of Biochemistry and Microbiology, Ghent University, K.L. Ledeganckstraat 35, 9000 Gent, Belgium
Author to whom correspondence should be addressed.
Antibiotics 2014, 3(3), 317-340;
Received: 8 April 2014 / Revised: 20 June 2014 / Accepted: 23 June 2014 / Published: 2 July 2014
(This article belongs to the Special Issue Mechanisms of Antibiotic Resistance)
Tuberculosis (TB) is a serious public health problem worldwide. Its situation is worsened by the presence of multidrug resistant (MDR) strains of Mycobacterium tuberculosis, the causative agent of the disease. In recent years, even more serious forms of drug resistance have been reported. A better knowledge of the mechanisms of drug resistance of M. tuberculosis and the relevant molecular mechanisms involved will improve the available techniques for rapid drug resistance detection and will help to explore new targets for drug activity and development. This review article discusses the mechanisms of action of anti-tuberculosis drugs and the molecular basis of drug resistance in M. tuberculosis. View Full-Text
Keywords: drug resistance; molecular mechanisms; Mycobacterium tuberculosis drug resistance; molecular mechanisms; Mycobacterium tuberculosis
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MDPI and ACS Style

Palomino, J.C.; Martin, A. Drug Resistance Mechanisms in Mycobacterium tuberculosis. Antibiotics 2014, 3, 317-340.

AMA Style

Palomino JC, Martin A. Drug Resistance Mechanisms in Mycobacterium tuberculosis. Antibiotics. 2014; 3(3):317-340.

Chicago/Turabian Style

Palomino, Juan Carlos, and Anandi Martin. 2014. "Drug Resistance Mechanisms in Mycobacterium tuberculosis" Antibiotics 3, no. 3: 317-340.

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