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Article

Characterization of Diarreaghenic Escherichia coli Strains Isolated from Healthy Donors, including a Triple Hybrid Strain

1
Departamento de Ciencias Químico Biológicas y Agropecuarias, Universidad de Sonora, Unidad Regional Norte, Campus Caborca. Av. Universidad e Irigoyen S/N, col. Eleazar Ortiz, H. Caborca CP 83621, Sonora, Mexico
2
Posgrado en Microbiología, Centro de Investigación en Ciencias Microbiológicas, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, Puebla CP 72570, Pue, Mexico
*
Authors to whom correspondence should be addressed.
Academic Editors: Juan C. Vázquez-Ucha and Marta Martínez-Guitián
Antibiotics 2022, 11(7), 833; https://doi.org/10.3390/antibiotics11070833
Received: 2 June 2022 / Revised: 19 June 2022 / Accepted: 20 June 2022 / Published: 21 June 2022
(This article belongs to the Special Issue Bacterial Pathogenesis and Antimicrobial Strategy)
Escherichia coli is a well-recognized inhabitant of the animal and human gut. Its presence represents an essential component of the microbiome. There are six pathogenic variants of E. coli associated with diarrheal processes, known as pathotypes. These harbor genetic determinants that allow them to be classified as such. In this work, we report the presence of diarrheagenic pathotypes of E. coli strains isolated from healthy donors. Ninety E. coli strains were analyzed, of which forty-six (51%) harbored virulence markers specifics for diarrheagenic pathotypes, including four hybrids (one of them with genetic determinants of three DEC pathotypes). We also identified phylogenetic groups with a higher prevalence of B2 (45.6%) and A (17.8%). In addition, resistance to sulfonamides (100%), and aminoglycosides (100%) was found in 100% of the strains, with a lower prevalence of resistance to cefotaxime (13.3%), ceftriaxone (12.2%), fosfomycin (10%), and meropenem (0%). All analyzed strains were classified as multidrug resistant. Virulence genes were also investigated, which led us to propose three new virotypes. Among the virulence traits observed, the ability to form biofilms stands out, which was superior to that of the E. coli and Staphylococcus aureus strains used as positive controls. View Full-Text
Keywords: Escherichia coli; pathotypes; healthy donors; antimicrobial resistance Escherichia coli; pathotypes; healthy donors; antimicrobial resistance
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MDPI and ACS Style

Méndez-Moreno, E.; Caporal-Hernandez, L.; Mendez-Pfeiffer, P.A.; Enciso-Martinez, Y.; De la Rosa López, R.; Valencia, D.; Arenas-Hernández, M.M.P.; Ballesteros-Monrreal, M.G.; Barrios-Villa, E. Characterization of Diarreaghenic Escherichia coli Strains Isolated from Healthy Donors, including a Triple Hybrid Strain. Antibiotics 2022, 11, 833. https://doi.org/10.3390/antibiotics11070833

AMA Style

Méndez-Moreno E, Caporal-Hernandez L, Mendez-Pfeiffer PA, Enciso-Martinez Y, De la Rosa López R, Valencia D, Arenas-Hernández MMP, Ballesteros-Monrreal MG, Barrios-Villa E. Characterization of Diarreaghenic Escherichia coli Strains Isolated from Healthy Donors, including a Triple Hybrid Strain. Antibiotics. 2022; 11(7):833. https://doi.org/10.3390/antibiotics11070833

Chicago/Turabian Style

Méndez-Moreno, Evelyn, Liliana Caporal-Hernandez, Pablo A. Mendez-Pfeiffer, Yessica Enciso-Martinez, Rafael De la Rosa López, Dora Valencia, Margarita M. P. Arenas-Hernández, Manuel G. Ballesteros-Monrreal, and Edwin Barrios-Villa. 2022. "Characterization of Diarreaghenic Escherichia coli Strains Isolated from Healthy Donors, including a Triple Hybrid Strain" Antibiotics 11, no. 7: 833. https://doi.org/10.3390/antibiotics11070833

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