Next Article in Journal
First Report of an Extensively Drug-Resistant ST23 Klebsiella pneumoniae of Capsular Serotype K1 Co-Producing CTX-M-15, OXA-48 and ArmA in Spain
Previous Article in Journal
Third Generation Cephalosporin Resistant Enterobacterales Infections in Hospitalized Horses and Donkeys: A Case–Case–Control Analysis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antibiotics
Volume 10
Issue 2
10.3390/antibiotics10020156
antibiotics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

The Effects of Antibiotics for Helicobacter pylori Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis

by
Jun Watanabe
,
Junya Shimamoto
and
Kazuhiko Kotani
*
Division of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City, Tochigi 329-0498, Japan
*
Author to whom correspondence should be addressed.
Antibiotics 2021, 10(2), 156; https://doi.org/10.3390/antibiotics10020156
Submission received: 29 December 2020 / Revised: 30 January 2021 / Accepted: 1 February 2021 / Published: 4 February 2021
Browse Figures
Versions Notes

Abstract

:
Background: Chronic spontaneous urticaria (CSU) is a disease with wheals and/or angioedema. Some drugs, especially antibiotics for Helicobacter pylori (H. pylori) eradication and the sulfone antibiotic dapsone, may be candidates for treating CSU. The present study assessed the efficacy of these antibiotic therapies for CSU. Methods: Databases (MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, the World Health Organization International Clinical Trials Platform Search Portal and ClinicalTrials.gov) were searched until October 2020. Study selection, data abstraction and quality assessments were independently performed using the Grading of Recommendations Assessment, Development and Evaluation approach. The outcomes were the remission of CSU-related symptoms, activities and adverse events due to antibiotics for H. pylori eradication or dapsone. Results: Nine randomized controlled trials (RCTs; 361 patients) were included. The antibiotics for H. pylori eradication increased the remission rate (risk ratio (RR) = 3.99, 95% confidence interval (CI) = 1.31 to 12.14; I2 = 0%), but dapsone did not (RR = 1.15, 95% CI = 0.74 to 1.78). Antibiotics for H. pylori eradication (standard mean difference (SMD) = 1.49, 95% CI = 0.80 to 2.18; I2 = 69%) and dapsone (SMD = 7.00, 95% CI = 6.92 to 7.08; I2 = 0%) improved symptoms. The evidence of certainty was moderate. Dapsone was associated with mild adverse events, whereas H. pylori eradication was not. Conclusion: Antibiotics, especially those for H. pylori eradication, improved the remission rate and symptoms of CSU with few adverse events. Further studies are needed.

1. Introduction

Chronic spontaneous urticaria (CSU) is a condition characterized by the development of wheals, angioedema or both and pruritus during a period of six or more weeks [1]. Chronic urticaria affects about 0.5–1% of the general population worldwide, and CSU accounts for over two-thirds of chronic urticaria cases, with affliction persisting for 20 years after the onset in up to 20% of patients [1,2,3]. CSU is not only an adult disease but also affects the pediatric population [4]. CSU thus has a significant impact on an impaired quality of life [5].
Previous systematic reviews showed that antibiotics for the eradication of chronic infections, such as Helicobacter pylori (H. pylori) infection, suppressed symptoms of CSU [6,7,8]. The antibiotics themselves might be more influential on this effect than the eradication of H. pylori [8]. The antibiotics used mainly for H. pylori eradication, such as amoxicillin, clarithromycin and metronidazole, may thus be closely involved in the pathology of CSU [7,8,9].
Dapsone is a sulfone antibiotic that can be used for antihistamine-refractory CSU; however, thus far, this drug is not fully recommended [1,2]. With this background, the quality of its supporting evidence in the guidelines was based on just one randomized control trial (RCT) and two case reports [10,11,12]. Therefore, the present study assessed the efficacy of antibiotics for chronic infections in CSU patients, especially antibiotics for H. pylori eradication and the sulfone antibiotic dapsone.

2. Methods

This review protocol was registered in protocol.io (https://www.dx.doi.org/10.17504/protocols.io.bq3qmymw, accessed on 4 February 2021), the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) Statement [13].

2.1. Literature Search and Study Selection

Only RCTs were included in our assessment of the effects of oral antibiotics on CSU, irrespective of language, observation period, year of publication, publication and unpublished data. The inclusion criteria were patients with CSU, defined as recurrent attacks of hives daily or almost daily persisting for six or more weeks [1]. The patients over 16 years old were included as the dose of antibiotics used at age 16 is generally the same as that for adults [14]. Oral antibiotics included the H. pylori eradication regimen and the sulfone antibiotic dapsone with immunomodulatory agents. The comparators were the corresponding placebo or no placebo. The outcomes were remission rates, improvement of CSU symptoms and adverse events. Remission of urticaria symptoms was defined as no attacks of wheals or pruritus at the end of the follow-up period [1]. The improvement of urticaria symptoms was defined by the difference in the urticaria activity score (UAS), which is the sum of the hives score and itch severity score, between the baselines and the end of follow-up [1]. When the total score was unknown, the urticaria (hives) score was adopted.
The electronic databases were searched using the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE via Ovid and EMBASE via PROQUEST (Appendix B). The clinical trial registrations were searched using the website of the World Health Organization International Clinical Trials Platform Search Portal (ICTRP) and ClinicalTrials.gov (Appendix B). The reference lists of guidelines were searched for articles related to urticaria [1,2,3]. The reference lists were also hand-searched from the included trials. The authors were contacted to obtain further data as necessary.

2.2. Data Extraction and Quality Assessments

Two review authors (J.W. and J.S.) independently completed the construction of databases, article screening, study quality assessment and data extraction. Discrepancies were resolved by discussion with the third review author (K.K.). Data were extracted using a standardized data extraction form. Information collected included the characteristics (author, year, country, patient number, age, antibiotics, control, follow-up periods and eradication rate) and data (outcomes) from the included studies. The risk of bias was assessed using version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB2) tool [15].

2.3. Data Synthesis and Analyses

Relative risks with 95% confidence intervals (CIs) were calculated for the remission rate. The standard mean differences (SMD) and 95% CIs were calculated for the improvement of CSU symptoms. All adverse events were summarized according to the definition of each study.
The statistical heterogeneity was first assessed by a visual inspection of the forest plot and using the I2 statistic (I2 values of 0% to 40%: may not be important; 30% to 60%: may represent moderate heterogeneity; 50% to 90%: may represent substantial heterogeneity; 75% to 100%; considerable heterogeneity) [15]. When heterogeneity was identified (I2 statistic > 50%), possible sources of heterogeneity were explored using subgroup analyses. The publication bias was evaluated by searching the clinical trial registries, but the funnel plot asymmetry was not assessed because the number of studies in each meta-analysis was <10 according to the Cochrane handbook [15]. In studies of H. pylori eradication, the subgroup analyses were H. pylori eradication rate: ≥80% versus <80% [6]. The following sensitivity analyses were performed: (1) only the participants who completed the study with full data and (2) exclusion of studies with a high overall risk of bias.
Meta-analyses with a random-effects model were performed using the Review Manager software program (RevMan 5.4.1). The findings for the outcomes were summarized in a table based on the Cochrane handbook [15]. The quality of evidence was evaluated by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach [16].

3. Results

3.1. Study Selection

Figure 1 shows the selection process. After the initial screening of titles and abstracts with 1274 records until 4 October 2020, 14 records were identified. After the full-text screening, three studies were excluded because of participants having urticaria but not chronic urticaria [17], non-RCTs [18] and inappropriate controls [19]. A total of 10 RCTs (including one trial without publication (IRCT2016082114333N56 [20])) were detected for the qualitative synthesis. Ultimately, 9 trials with 361 participants were included in the quantitative synthesis because 1 trial did not report the remission rate or clinical improvement of urticarial-related symptoms in the control groups [21].
Table 1 summarizes the characteristics of the studies included in the quantitative synthesis [10,22,23,24,25,26,27,28,29]. Antibiotics were used in the H. pylori eradication regimen in six trials, while dapsones was used in three trials. The follow-up periods were within three months in five trials and beyond three months in four trials. Table 2, Table A1 and Table A2 show the risk of bias. Overall, only one study had a high risk of bias due to deviations from intended interventions, missing outcome data and an unclear measurement of the outcomes.

3.2. Outcomes

Table 3 shows the summary of findings, which include an overall grading of the evidence related to each of the outcomes using the GRADE approach [16].

3.2.1. Remission Rate

Regarding the remission rate of CSU, four studies on H. pylori and one study on dapsone were identified [10,22,23,24,27]. The H. pylori eradication regimen increased the remission rate of CSU (RR = 3.99, 95% CI = 1.31 to 12.14; I2 = 0%) (Figure 2) [22,23,24,27]. Dapsone resulted in little to no difference in the remission rate (RR = 1.15, 95% CI = 0.74 to 1.78) [8]. The evidence of certainty was moderate.

3.2.2. Clinical Improvement

Regarding the improvement in CSU, two studies on H. pylori and two studies on dapsone were identified [10,25,26,29]. The H. pylori eradication regimen resulted in a slight increase in clinical improvement (SMD = 1.49, 95% CI = 0.80 to 2.18; I2 = 69%) (Figure 3) [22,23]. Dapsone resulted in a large increase in clinical improvement (SMD = 7.00, 95% CI = 6.92 to 7.08; I2 = 0%) [26,29]. Controls showed little to no effect on the clinical improvement of CSU (SMD = 0.62, 95% CI = 0.31 to 0.93; I2 = 0%) (Figure 4) [10,25,26,29]. The evidence of certainty was moderate.

3.2.3. Adverse Events

One study on H. pylori and three studies on dapsone were identified. One study on H. pylori and one study on dapsone reported no adverse events [10,13,28,29]. One study on dapsone reported that 3/38 (7.9%) patients in dapsone groups had drug-related symptoms (nausea in 2 patients and fatigue and headache in 1 patient), and 1/27 (3.7%) patients in control groups had gastrointestinal upset [10]. In another study on dapsone, 4/10 (40%) patients in dapsone groups had adverse events (nausea in 2 patients, vaginal candidiasis in 1 patient and mild neuropathy in 1 patient), and 3/12 (25%) patients in control groups had viral respiratory infections [29]. The evidence of certainty was low.

3.3. Additional Analyses

In the subgroup analysis of the H. pylori eradication rate, an H. pylori eradication rate ≥80% (RR = 4.89, 95% CI = 1.31 to 18.17; I2 = 0%) increased the remission rate of CSU, but not an H. pylori eradication rate <80% (RR = 2.40, 95% = CI 0.30 to 19.34) (Figure A1). The prespecified sensitivity analyses were consistent with the primary findings (Figure A2 and Figure A3).

4. Discussion

H. pylori infection is thought to have a potential trigger for CUS, and it is thus searched during the diagnostic work-up of CSU, even though the epidemiological/clinical evidence is not very strong, or at least inconsistent [30,31]. In the present systematic review and meta-analyses, antibiotic therapy for H. pylori eradication increased the remission rate and induced improvement in CSU with few adverse events. Dapsone might not increase the remission rates and could improve CSU with mild adverse events. Given the results of RCTs only, both antibiotics were recognized to be useful for CSU.
There is an earlier review showing that antibiotics for H. pylori eradication suppressed CSU symptoms and improved remission with or without H. pylori eradication [8]. In our subgroup analysis, high eradication rates of H. pylori increased remission of CSU, while low eradication rates did not. Keeping such observations in mind, we consider several hypotheses concerning the mechanisms of the effect of antibiotics on CSU: (1) alleviation of inflammation, (2) favorable modulation of gut microbiota or (3) eradication of H. pylori itself (in CUS patients with H. pylori infection) [32]. First, CUS-related systemic inflammation is caused by activated mast cells and induced cytokines [33,34]. Some antibiotics, such as clarithromycin, attenuate proinflammatory cytokine production during the innate immune response by inhibiting Th2 cytokine secretion [35]. Second, the diversity of the microbiota is a regulator in the gut–skin axis [36,37,38,39]. Antibiotics can modulate favorably the microbiota, resulting in the reduction of systemic inflammation [40]. In addition, as H. pylori itself induced the release of histamine by mast cells, H. pylori eradication by antibiotics would have a favorable effect on the pathophysiology of CSU [41,42].
In the guidelines that included only one RCT in Europe, dapsone had little evidence on CSU [1,2]. The present review included three RCTs, suggesting that dapsone might not increase the remission rates but did improve the symptoms. The significant improvement in the symptoms by dapsone is important because patients with CSU have an impaired quality of life due to their symptoms [43]. The mechanism underlying the effects of dapsone on CSU remains unclear, but dapsone cannot affect H. pylori. The various anti-inflammatory effects of dapsone seem to be involved; namely, dapsone prevents the production of 5-lipoxygenase products in neutrophils, downregulates leukotrienes and inhibits prostaglandin and leukotriene activities [44,45,46,47,48].
Our present finding that adverse events may be more likely to occur with dapsone than with H. pylori eradication should be interpreted with caution. In our review, only one of the six studies concerning H. pylori eradication reported adverse events, while all three studies concerning dapsone reported these data. In previous systematic reviews, antibiotic therapy for H. pylori eradication increased the rate of mild adverse events, such as gastrointestinal symptoms, compared to no eradication therapy [49,50]. Furthermore, dapsone has been safely used in the long term as a treatment for leprosy. However, patients using dapsone require regular examinations, as this agent causes some rare but major adverse events, such as met-hemoglobinemia, hemolysis, agranulocytosis and peripheral neuropathy with primarily motor function loss [43].
The present review has strengths compared to the previous systematic reviews [6,7,8]. First, a rigorous methodology was adopted according to the PRISMA statement [13], including a comprehensive search and duplicate assessments for evidence. Second, the GRADE approach was used to assess the certainty of the evidence [16]. Although the certainty was very low in a previous systematic review [6], the present review showed moderate evidence and provided a practical estimate of the effects of antibiotics for CUS. The present review had several limitations. First, this review included only antibiotics for H. pylori eradication and dapsone. Although previous studies have largely focused on antibiotics of H. pylori itself and inflammation, further studies focusing on three mechanisms, including gut microbiota, are needed. As candidates of other antibiotics, tetracycline used in bismuth quadruple therapy has a high eradication rate of H. pylori and improves urticaria [17,51]. Second, all studies included in this review had a small sample size. Further large-scale studies are needed to increase the certainty and generalizability of the evidence.

5. Conclusions

In conclusion, the present systematic review and meta-analysis showed that antibiotic therapies, especially those for H. pylori eradication, improved the remission rates and symptoms of CSU with few adverse events. These findings provide relevant information that physicians can use antibiotics for CSU. Further studies are warranted to assess the efficacy and safety of antibiotics on CSU.

Author Contributions

Conceptualization, J.W. and K.K.; methodology, J.W. and K.K; software, J.W.; validation, J.W., J.S. and K.K; formal analysis, J.W. and K.K.; investigation, J.W., J.S. and K.K; resources, N/A; data curation, J.W., J.S. and K.K.; writing—original draft preparation, J.W.; writing, review and editing, J.W., J.S. and K.K; visualization, J.W.; supervision, K.K.; project administration, J.W. and K.K; funding acquisition, N/A. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Conflicts of Interest

The authors declare no conflict of interests.

Abbreviations

CI = confidence interval, CSU = chronic spontaneous urticaria, H. pylori = Helicobacter pylori, RCT = randomized controlled trials, RR = risk ratio, SMD = standard mean difference.

Appendix A

Antibiotics 10 00156 g0a1 550
Figure A1. Forest plot of the remission rate with H. pylori eradication rate: ≥80% versus <80%.
Figure A1. Forest plot of the remission rate with H. pylori eradication rate: ≥80% versus <80%.
Antibiotics 10 00156 g0a1
Antibiotics 10 00156 g0a2 550
Figure A2. Forest plot of the remission rate including only studies of the participants who completed the study with full data.
Figure A2. Forest plot of the remission rate including only studies of the participants who completed the study with full data.
Antibiotics 10 00156 g0a2
Antibiotics 10 00156 g0a3 550
Figure A3. Forest plot of the remission rate excluding studies with a high overall risk of bias.
Figure A3. Forest plot of the remission rate excluding studies with a high overall risk of bias.
Antibiotics 10 00156 g0a3
Table
Table A1. Quality scores for the eligibility studies for clinical improvement.
Table A1. Quality scores for the eligibility studies for clinical improvement.
Authors.
(Ref No.)		Risk of Bias 2 Tool Assessment
Bias Arising from the Randomization ProcessBias due to Deviations from Intended InterventionsBias due to Missing Outcome DataBias in Measurement of the OutcomeBias in Selection of the Reported ResultsOverall Risk of Bias
Magen [25]Some concernsLowLowSome concernsSome concernsSome concerns
Pawłowicz [26]Some concernsLowLowLowSome concernsSome concerns
Engin [10]Some concernsLowLowSome concernsSome concernsSome concerns
Morgan [29]LowLowLowLowSome concernsSome concerns
Table
Table A2. Quality scores for the eligibility studies for adverse events.
Table A2. Quality scores for the eligibility studies for adverse events.
Authors
(Ref No.)		Risk of Bias 2 Tool Assessment
Bias Arising from the Randomization ProcessBias due to Deviations from Intended InterventionsBias due to Missing Outcome DataBias in Measurement of the OutcomeBias in Selection of the Reported ResultsOverall Risk of Bias
Gaig [24]Some concernsLowLowLowSome concernsSome concerns
Engin [10]Some concernsLowLowHighSome concernsHigh
Rajan [28]Some concernsLowHighHighSome concernsHigh
Morgan [29]LowLowLowLowSome concernsSome concerns

Appendix B

Search strategy of the electronic databases
CENTRAL search strategy
  • MeSH descriptor: [Urticaria] explode all trees
  • urticaria:ti,ab,kw (Word variations have been searched)
  • hives:ti,ab,kw (Word variations have been searched)
  • 1. OR 2. OR 3.
  • MeSH descriptor:[Anti-Bacterial Agents]explode all tree
  • 6 (antibiotic* or antibacteri* or anti* bacter* or bacteriocid* or bactericid* or anti*microbial or ciprofloxacin or metronidazole or levamisole or ornidazole or fusidin or rifaximin or vancomycin or fusidic acid or nitazoxanide or teicoplanin or rifampicin or bacitracin or fidaxomicin or amoxicillin or azithromycin or cephalosporin* or cephalexin or clarithromycin or clindamycin or doxycycline or erythromycin or fluoroquinolone* or levofloxacin or macrolide* or nitrofurantoin or penicillin or tetracycline or trimethoprim or dapsone):ti,ab,kw (Word variations have been searched)
  • 5. OR 6
  • MeSH descriptor: [Helicobacter] explode all trees
  • MeSH descriptor: [Helicobacter Infections] explode all trees
  • MeSH descriptor: [Helicobacter pylori] explode all trees
  • 11 (helicobacter or pylori or pyloridis or Campylobacter):ti,ab,kw (Word variations have been searched)
  • 8. OR 9. OR 10. OR 11.
  • 13 7. OR 12.
  • 4. AND 13.
MEDLINE (via Ovid) search strategy
  • exp Urticaria/
  • urticaria.tw.
  • hives.tw.
  • or/1–3
  • exp Anti-bacterial Agents/
  • (antibiotic$ or antibacteri$ or anti$bacter$ or bacteriocid$ or bactericid$ or anti$microbial or ciprofloxacin or metronidazole or levamisole or ornidazole or fusidin or rifaximin or vancomycin or fusidic acid or nitazoxanide or teicoplanin or rifampicin or bacitracin or fidaxomicin or amoxicillin or azithromycin or cephalosporin$ or cephalexin or clarithromycin or clindamycin or doxycycline or erythromycin or fluoroquinolone$ or levofloxacin or macrolide$ or nitrofurantoin or penicillin or tetracycline or trimethoprim or dapsone).tw.
  • or/5–6
  • exp Helicobacter pylori/ or exp Helicobacter/ or exp Helicobacter infection/
  • (pylori or pyloridis or HP).tw.
  • (helicobacter or Campylobacter).tw.
  • or/8–10
  • 7 or 11
  • 4 and 12
  • ((randomized controlled trial or controlled clinical trial).pt. or randomized.ab. or randomised.ab. or placebo.ab. or drug therapy.fs. or randomly.ab. or trial.ab. or groups.ab.) not (exp animals/ not humans.sh.)
  • 13 and 14
EMBASE (via PROQUEST) search strategy
  • S1. EMB.EXACT.EXPLODE(“chronic urticaria”)
  • S2. (ab(urticaria) OR ti(urticaria))
  • S3. (ab(hives) OR ti(hives))
  • S4. S1 OR S2 OR S3
  • S5. EMB.EXACT.EXPLODE(“antibiotic agent”)
  • S6. (ab(antibiotic) OR ti(antibiotic) OR ab(antibiotics) OR ti(antibiotics))
  • S7. (ab(antibacterial) OR ti(antibacterial) OR ab(anti bacteral) OR ti(anti bacteral))
  • S8. (ab(bacteriocidal) OR ti(bacteriocidal) OR ab(bactericidal) OR ti(bactericidal) OR ab(anti microbial) OR ti(anti microbial))
  • S9. (ab(ciprofloxacin) OR ti(ciprofloxacin) OR ab(metronidazole) OR ti(metronidazole) OR ab(levamisole) OR ti(levamisole) OR ab(ornidazole) OR ti(ornidazole) OR ab(fusidin) OR ti(fusidin) OR ab(rifaximin) OR ti(rifaximin) OR ab(vancomycin) OR ti(vancomycin) OR ab(fusidic acid) OR ti(fusidic acid) OR ab(nitazoxanide) OR ti(nitazoxanide) OR ab(teicoplanin) OR ti(teicoplanin) OR ab(rifampicin) OR ti(rifampicin) OR ab(bacitracin) OR ti(bacitracin) OR ab(fidaxomicin) OR ti(fidaxomicin) OR ab(amoxicillin) OR ti(amoxicillin) OR ab(azithromycin) OR ti(azithromycin) OR ab(cephalosporin) OR ti(cephalosporin) OR ab(cephalosporinic) OR ti(cephalosporinic) OR ab(cephalexin) OR ti(cephalexin) OR ab(clarithromycin) OR ti(clarithromycin) OR ab(clindamycin) OR ti(clindamycin) OR ab(doxycycline) OR ti(doxycycline) OR ab(erythromycin) OR ti(erythromycin) OR ab(flouroquinolone) OR ti(flouroquinolone) OR ab(levofloxacin) OR ti(levofloxacin) OR ab(macrolide) OR ti(macrolide) OR ab(nitrofurantoin) OR ti(nitrofurantoin) OR ab(penicillin) OR ti(penicillin) OR ab(tetracycline) OR ti(tetracycline) OR ab(trimethoprim) OR ti(trimethoprim) OR ab(dapsone) OR ti(dapsone))
  • S10. S5 OR S6 OR S7 OR S8 OR S9
  • S11. EMB.EXACT.EXPLODE(“Helicobacter pylori”)
  • S12. EMB.EXACT.EXPLODE(“Helicobacter”)
  • S13. EMB.EXACT.EXPLODE(“Helicobacter infection”)
  • S14. (ab(pylori or pyloridis or HP) OR ti(pylori or pyloridis or HP))
  • S15. (ab(helicobacter or Campylobacter) OR ti(helicobacter or Campylobacter))
  • S16. S11 OR S12 OR S13 OR S14 OR S15
  • S17. S10 OR S16
  • S18. S4 AND S17
  • S19. (ab(random*) OR ti(random*)) OR (ab(placebo*) OR ti(placebo*)) OR (ab(double NEAR/1 blind*) OR ti(double NEAR/1 blind*))
  • S20. S18 AND S19
ClinicalTrials.gov. search strategy
Condition or disease: chronic urticaria
ICTRP search strategy
chronic urticaria

References

  1. Leech, S.; Grattan, C.; Lloyd, K.; Deacock, S.; Williams, L.; Langford, A.; Warner, J. The RCPCH care pathway for children with Urticaria, Angio-oedema or Mastocytosis: An evidence and consensus based national approach. Arch. Dis. Child. 2011, 96, i34–i37. [Google Scholar] [CrossRef]
  2. Powell, R.J.; Leech, S.C.; Till, S.; Huber, P.A.J.; Nasser, S.M.; Clark, A. BSACI guideline for the management of chronic urticaria and angioedema. Clin. Exp. Allergy 2015, 45, 547–565. [Google Scholar] [CrossRef] [PubMed]
  3. Zuberbier, T.; Aberer, W.; Asero, R.; Abdul Latiff, A.H.; Baker, D.; Ballmer-Weber, B.; Bernstein, J.A.; Bindslev-Jensen, C.; Brzoza, Z.; Buense Bedrikow, R.; et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy 2018, 73, 1393–1414. [Google Scholar] [CrossRef] [PubMed]
  4. Poddighe, D. The prevalence of chronic spontaneous urticaria (CSU) in the pediatric population. J. Am. Acad. Dermatol. 2019, 81, e149. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  5. Mustafa, S.S.; Sánchez-Borges, M. Chronic Urticaria: Comparisons of US, European, and Asian Guidelines. Curr. Allergy Asthma Rep. 2018, 18, 36. [Google Scholar] [CrossRef] [PubMed]
  6. Shakouri, A.; Compalati, E.; Lang, D.M.; A Khan, D. Effectiveness of Helicobacter pylori eradication in chronic urticaria: Evidence-based analysis using the Grading of Recommendations Assessment, Development, and Evaluation system. Curr. Opin. Allergy Clin. Immunol. 2010, 10, 362–369. [Google Scholar] [CrossRef]
  7. Cornillier, H.; Giraudeau, B.; Munck, S.; Hacard, F.; Jonville-Bera, A.-P.; D’Acremont, G.; Pham, B.-N.; Maruani, A. Chronic spontaneous urticaria in children—A systematic review on interventions and comorbidities. Pediatr. Allergy Immunol. 2018, 29, 303–310. [Google Scholar] [CrossRef]
  8. Kim, H.J.; Kim, Y.-J.; Lee, H.J.; Hong, J.Y.; Park, A.Y.; Chung, E.H.; Lee, S.Y.; Lee, J.S.; Park, Y.L.; Lee, S.H.; et al. Systematic review and meta-analysis: Effect of Helicobacter pylori eradication on chronic spontaneous urticaria. Helicobacter 2019, 24, e12661. [Google Scholar] [CrossRef]
  9. Akashi, R.; Ishiguro, N.; Shimizu, S.; Kawashima, M. Clinical study of the relationship between Helicobacter pylori and chronic urticaria and prurigo chronica multiformis: Effectiveness of eradication therapy for Helicobacter pylori. J. Dermatol. 2010, 38, 761–766. [Google Scholar] [CrossRef]
  10. Engin, B.; Özdemir, M. Prospective randomized non-blinded clinical trial on the use of dapsone plus antihistamine vs. antihistamine in patients with chronic idiopathic urticaria. J. Eur. Acad. Dermatol. Venereol. 2008, 22, 481–486. [Google Scholar] [CrossRef]
  11. González, P.; Soriano, V.; Caballero, T.; Niveiro, E. Idiopatic angioedema treated with dapsone. Allergol. Immunopathol. 2005, 33, 54–56. [Google Scholar] [CrossRef] [PubMed]
  12. Eiser, A.R.; Singh, P.; Shanies, H.M. Sustained dapsone-induced remission of hypocomplementemic urticarial vasculitis—A case report. Angiology 1997, 48, 1019–1022. [Google Scholar] [CrossRef]
  13. Liberati, A.; Altman, D.G.; Tetzlaff, J.; Mulrow, C.D.; Gøtzsche, P.C.; Ioannidis, J.P.A.; Clarke, M.; Devereaux, P.J.; Kleijnen, J.; Moher, D. The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration. PLoS Med. 2009, 6, e1000100. [Google Scholar] [CrossRef]
  14. Kimko, H.H.C.; Thyssen, A.; Mould, D.R.; Mannaert, E.; Treem, W.R. Helicobacter pyloritreatment in children: Defining a dose for rabeprazole as a part of a triple therapy regimen. J. Clin. Pharmacol. 2015, 55, 592–600. [Google Scholar] [CrossRef]
  15. Cumpston, M.; Li, T.; Page, M.J.; Chandler, J.; A Welch, V.; Higgins, J.P.; Thomas, J. Updated guidance for trusted systematic reviews: A new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst. Rev. 2019, 10, ED000142. [Google Scholar] [CrossRef] [Green Version]
  16. Guyatt, G.; Oxman, A.D.; Akl, E.A.; Kunz, R.; Vist, G.; Brozek, J.; Norris, S.; Falck-Ytter, Y.; Glasziou, P.; Debeer, H. GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables. J. Clin. Epidemiol. 2011, 64, 383–394. [Google Scholar] [CrossRef]
  17. Pasricha, J.S. Therapeutic Effect of Anti- Bacterial Agents in Urticaria. Indian J. Dermatol. Venereol. Leprol. 1979, 45, 344–347. [Google Scholar]
  18. Gorczyza, M.; Schoepke, N.; Krause, K.; Hawro, T.; Maurer, M. Patients with chronic cold urticaria may benefit from doxycycline therapy. Br. J. Dermatol. 2016, 176, 259–261. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  19. Yang, X.-L.; Jia, Q.-L.; Liu, P.-H.; Jin, W.-J.; Zhou, Y.; Wang, L.-X.; Gao, X.-G. Efficacy observation on acupoint catgut embedding therapy combined medication for treatment of chronic urticaria induced by Helicobacter pylori infection. Zhongguo Zhen Jiu Chin. Acupunct. Moxibustion 2010, 30, 993–996. [Google Scholar]
  20. Feizollah, F. Study of the effect of medications used to treat Helicobacter pylori infection on quality of life in chronic idiopathic urticaria. 2016. Available online: https://en.irct.ir/trial/13988 (accessed on 23 December 2020).
  21. Akelma, A.; Cizmeci, M.; Mete, E.; Tufan, N.; Bozkurt, B. A neglected cause for chronic spontaneous urticaria in children: Helicobacter pylori. Allergol. Immunopathol. 2015, 43, 259–263. [Google Scholar] [CrossRef] [PubMed]
  22. Valsecchi, R.; Pigatto, P. Chronic urticaria and Helicobacter pylori. Acta Derm. Venereol. 1998, 78, 440–442. [Google Scholar]
  23. Schnyder, B.; Helbling, A.; Pichler, W.J. Chronic Idiopathic Urticaria: Natural Course and Association with Helicobacter pylori Infection. Int. Arch. Allergy Immunol. 1999, 119, 60–63. [Google Scholar] [CrossRef]
  24. Gaig, P.; García-Ortega, P.; Enrique, E.; Papo, M.; Quer, J.; Richard, C. Efficacy of the eradication of Helicobacter pylori infection in patients with chronic urticaria. A placebo-controlled double blind study. Allergol. Immunopathol. 2002, 30, 255–258. [Google Scholar] [CrossRef]
  25. Magen, E.; Mishal, J.; Schlesinger, M.; Scharf, S. Eradication of Helicobacter pylori Infection Equally Improves Chronic Urticaria With Positive and Negative Autologous Serum Skin Test. Helicobacter 2007, 12, 567–571. [Google Scholar] [CrossRef] [PubMed]
  26. Pawłowicz, R.; Wytrychowski, K.; Panaszek, B. Eradication of Helicobacter pylori, as add-on therapy, has a significant, but temporary influence on recovery in chronic idiopathic urticaria: A placebo-controlled, double blind trial in the Polish population. Adv. Dermatol. Allergol. 2018, 35, 151–155. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  27. Elhendawy, M.; Hagras, M.M.; Soliman, S.S.; E Shaker, E.S. Positive Effect of Helicobacter pylori Treatment on Outcome of Patients With Chronic Spontaneous Urticaria. Am. J. Clin. Pathol. 2020, 134. [Google Scholar] [CrossRef]
  28. Rajan, N.; Darne, S.; Ah-Weng, A.; Carmichael, A. Dapsone as adjuvant treatment in chronic ordinary urticaria: Positive implications for quality of life. Br. J. Dermatol. 2010, 163, 49. [Google Scholar]
  29. Morgan, M.; Cooke, A.; Rogers, L.; Adams-Huet, B.; Khan, D.A. Double-Blind Placebo-Controlled Trial of Dapsone in Antihistamine Refractory Chronic Idiopathic Urticaria. J. Allergy Clin. Immunol. Pr. 2014, 2, 601–606. [Google Scholar] [CrossRef]
  30. De Amici, M.; Marseglia, G.L. Spontaneous (Autoimmune) Chronic Urticaria in Children: Current Evidences, Diagnostic Pitfalls and Therapeutic Management. Recent Patents Inflamm. Allergy Drug Discov. 2016, 10, 34–39. [Google Scholar] [CrossRef]
  31. Kohli, S.; Mahajan, V.K.; Rana, B.S.; Mehta, K.S.; Raina, R.K.; Chauhan, P.S.; Sharma, V.; Rawat, R. Clinicoepidemiologic Features of Chronic Urticaria in Patients with versus without Subclinical Helicobacter pylori Infection: A Cross-Sectional Study of 150 Patients. Int. Arch. Allergy Immunol. 2018, 175, 114–120. [Google Scholar] [CrossRef]
  32. Bansal, C.J.; Bansal, A.S. Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria. Allergy Asthma Clin. Immunol. 2019, 15, 1–11. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  33. Desai, A.; Jung, M.-Y.; Olivera, A.; Gilfillan, A.M.; Prussin, C.; Kirshenbaum, A.S.; Beaven, M.A.; Metcalfe, D.D. IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3. J. Allergy Clin. Immunol. 2016, 137, 1863–1871.e6. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  34. Varghese, R.; Rajappa, M.; Chandrashekar, L.; Kattimani, S.; Archana, M.; Munisamy, M.; Revathy, G.; Thappa, D.M. Association among stress, hypocortisolism, systemic inflammation, and disease severity in chronic urticaria. Ann. Allergy Asthma Immunol. 2016, 116, 344–348.e1. [Google Scholar] [CrossRef] [PubMed]
  35. Ivetić Tkalčević, V.; Čužić, S.; Kramarić, M.D.; Parnham, M.J.; Haber, V.E. Topical Azithromycin and Clarithromycin Inhibit Acute and Chronic Skin Inflammation in Sensitized Mice, with Apparent Selectivity for Th2-Mediated Processes in Delayed-Type Hypersensitivity. Inflammation 2011, 35, 192–205. [Google Scholar] [CrossRef] [PubMed]
  36. Salem, I.; Ramser, A.; Isham, N.; Ghannoum, M.A. The Gut Microbiome as a Major Regulator of the Gut-Skin Axis. Front. Microbiol. 2018, 9, 1459. [Google Scholar] [CrossRef] [Green Version]
  37. Zhao, Y.; Gao, X.; Guo, J.; Yu, D.; Xiao, Y.; Wang, H.; Li, Y. Helicobacter pyloriinfection alters gastric and tongue coating microbial communities. Helicobacter 2019, 24, e12567. [Google Scholar] [CrossRef] [Green Version]
  38. Lu, T.; Chen, Y.; Guo, Y.; Sun, J.; Shen, W.; Yuan, M.; Zhang, S.; He, P.; Jiao, X. Altered Gut Microbiota Diversity and Composition in Chronic Urticaria. Dis. Markers 2019, 2019, 1–11. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  39. Nabizadeh, E.; Jazani, N.H.; Bagheri, M.; Shahabi, S. Association of altered gut microbiota composition with chronic urticaria. Ann. Allergy Asthma Immunol. 2017, 119, 48–53. [Google Scholar] [CrossRef] [Green Version]
  40. Rolig, A.S.; Cech, C.; Ahler, E.; Carter, J.E.; Ottemann, K.M. The Degree of Helicobacter pylori-Triggered Inflammation Is Manipulated by Preinfection Host Microbiota. Infect. Immun. 2013, 81, 1382–1389. [Google Scholar] [CrossRef] [Green Version]
  41. Tan, R.; Sun, H.; Zhang, W.; Yuan, H.; Li, B.; Yan, H.; Lan, C.; Yang, J.; Zhao, Z.; Wu, J. A 21-35 kDa Mixed Protein Component from Helicobacter pylori Activates Mast Cells Effectively in Chronic Spontaneous Urticaria. Helicobacter 2016, 21, 565–574. [Google Scholar] [CrossRef]
  42. Hong, G.U.; Ro, J.Y.; Bae, Y.; Kwon, I.-H.; Park, G.-H.; Choi, Y.H.; Choi, J.-H. Association of TG2 from mast cells and chronic spontaneous urticaria pathogenesis. Ann. Allergy Asthma Immunol. 2016, 117, 290–297. [Google Scholar] [CrossRef]
  43. O’Donnell, B.F.; Lawlor, F.; Simpson, J.; Morgan, M.; Greaves, M.W. The impact of chronic urticaria on the quality of life. Br. J. Dermatol. 1997, 136, 197–201. [Google Scholar] [CrossRef]
  44. Wozel, G.; Blasum, C. Dapsone in dermatology and beyond. Arch. Dermatol. Res. 2014, 306, 103–124. [Google Scholar] [CrossRef] [Green Version]
  45. Wozel, G.; Blasum, C.; Winter, C.; Gerlach, B. Dapsone hydroxylamine inhibits the LTB4-induced chemotaxis of polymorphonuclear leukocytes into human skin: Results of a pilot study. Inflamm. Res. 1997, 46, 420–422. [Google Scholar] [CrossRef]
  46. Wozel, G.; Lehmann, B. Dapsone Inhibits the Generation of 5-Lipoxygenase Products in Human Polymorphonuclear Leukocytes. Ski. Pharmacol. Physiol. 1995, 8, 196–202. [Google Scholar] [CrossRef] [PubMed]
  47. A Booth, S.; E Moody, C.; Dahl, M.V.; Herron, M.J.; Nelson, R.D. Dapsone Suppresses Integrin-Mediated Neutrophil Adherence Function. J. Investig. Dermatol. 1992, 98, 135–140. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  48. Bonney, R.J.; Wightman, P.D.; Dahlgren, M.E.; Sadowski, S.J.; Davies, P.; Jensen, N.; Lanza, T.; Humes, J.L. Inhibition of the release of prostaglandins, leukotrienes and lysosomal acid hydrolases from macrophages by selective inhibitors of lecithin biosynthesis. Biochem. Pharmacol. 1983, 32, 361–366. [Google Scholar] [CrossRef]
  49. Du, L.J.; Chen, B.R.; Kim, J.J.; Kim, S.; Shen, J.H.; Dai, N. Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis. World J. Gastroenterol. 2016, 22, 3486–3495. [Google Scholar] [CrossRef] [PubMed]
  50. Chen, M.-J.; Chen, C.-C.; Chen, Y.-N.; Chen, C.-C.; Fang, Y.-J.; Lin, J.-T.; Wu, M.-S.; Liou, J.-M.; For the Taiwan Gastrointestinal Disease and Helicobacter Consortium. Systematic Review with Meta-Analysis: Concomitant Therapy vs. Triple Therapy for the First-Line Treatment of Helicobacter pylori Infection. Am. J. Gastroenterol. 2018, 113, 1444–1457. [Google Scholar] [CrossRef]
  51. Liou, J.-M.; Chen, C.-C.; Chang, C.-M.; Fang, Y.-J.; Bair, M.-J.; Chen, P.-Y.; Chang, C.-Y.; Hsu, Y.-C.; Chen, M.-J.; Chen, C.-C.; et al. Long-term changes of gut microbiota, antibiotic resistance, and metabolic parameters after Helicobacter pylori eradication: A multicentre, open-label, randomised trial. Lancet Infect. Dis. 2019, 19, 1109–1120. [Google Scholar] [CrossRef]
Antibiotics 10 00156 g001 550
Figure 1. Flow diagram of the literature search results.
Figure 1. Flow diagram of the literature search results.
Antibiotics 10 00156 g001
Antibiotics 10 00156 g002 550
Figure 2. Forest plot of the remission rate.
Figure 2. Forest plot of the remission rate.
Antibiotics 10 00156 g002
Antibiotics 10 00156 g003 550
Figure 3. Forest plot of the clinical improvement in antibiotics.
Figure 3. Forest plot of the clinical improvement in antibiotics.
Antibiotics 10 00156 g003
Antibiotics 10 00156 g004 550
Figure 4. Forest plot of the clinical improvement in controls.
Figure 4. Forest plot of the clinical improvement in controls.
Antibiotics 10 00156 g004
Table
Table 1. Summary of the characteristics of the eligible studies.
Table 1. Summary of the characteristics of the eligible studies.
Authors
(Ref No.)		YearCountrySubject No.Age
(Years)		Antibiotics
(Months)		ControlFollow-Up
(Months)		Eradication Rate (%)
Valsecchi [22]1998Italy6524–61CMO (7)No placebo1293.5
Schnyder [23]1999Switzerland1134–73AL (14)Placebo220.0
Gaig [24]2002Spain1627–55ACO (7)Placebo1.5100
Magen [25]2007Israel7842.5 (6.8) *ACO (14)No placebo486.7
Pawłowicz [26]2018Poland6442.8 (13.3) **ACO (7)Placebo/no placebo691.7
El-hendawy [27]2020Egypt2730.9 (7.9)ACO (14)Placebo285.7
Engin [10]2007Turkey6516–60DapsoneNo Placebo6-
Rajan [28]2010United Kingdom13-DapsonePlacebo4-
Morgan [29]2014USA2225–64DapsonePlacebo1.5-
A, amoxicillin; C, clarithromycin; L, lansoprazole; M, metronidazole; O, omeprazole. * Age of the group with positive autologous serum skin test and 13C-urea breath test findings. ** Age of all participants enrolled in the study.
Table
Table 2. Quality scores for the eligible studies for remission rate.
Table 2. Quality scores for the eligible studies for remission rate.
Authors
(Ref No.)		Risk of Bias 2 Tool Assessment
Bias Arising from the Randomization ProcessBias due to Deviations from Intended InterventionsBias due to Missing Outcome DataBias in Measurement of the OutcomeBias in Selection of the Reported ResultsOverall Risk of Bias
Valsecchi [22]Some concernsHighHighHighSome concernsHigh
Schnyder [23]Some concernsLowLowLowSome concernsSome concerns
Gaig [24]Some concernsLowLowLowSome concernsSome concerns
Elhendawy [27]LowLowLowLowSome concernsSome concerns
Engin [10]LowSome concernsLowSome concernsSome concernsSome concerns
Table
Table 3. Summary of findings.
Table 3. Summary of findings.
The Efficacy and Safety of Antibiotics for Chronic Spontaneous Urticaria
Patient or Population: Adults
Setting: Chronic Spontaneous Urticaria
Intervention: Antibiotics
Comparison: Control
OutcomesAnticipated Absolute Effects * (95% CI) Relative Effect(95% CI) Patient Number(Studies) Certainty of the Evidence (GRADE) Comments
Risk with ControlRisk with Antibiotics
Remission rate178 per 1000421 per 1000 (153 to 1000)RR = 2.37
(0.86 to 6.51)		222
(5 RCTs) 		Moderate aThe H. pylori eradication regimen likely increased the remission rate of chronic urticaria, but not dapsone.
Clinical improvement-SMD 3.59 SD higher
(0.16 to 7.03) 		-229
(4 RCTs) 		Moderate aAntibiotics (H. pylori eradication regimen and dapsone) likely increased the improvement of chronic urticaria.
Adverse events0% in a study of H. pylori eradication, 11.5% in 3 studies of dapsone.117
(5 RCTs) 		Low a,bDapsone had mild adverse events, such as nausea, fatigue, and headache.
CI, confidence interval; RR, risk ratio; SMD, standard mean difference. * The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). GRADE Working Group grades of evidence: High certainty: We are very confident that the true effect lies close to that of the estimated effect. Moderate certainty: We are moderately confident in the estimated effect. The true effect is likely to be close to the estimated effect, but there is a possibility that it is substantially different. Low certainty: Our confidence in the estimated effect is limited. The true effect may be substantially different from the estimated effect. Very low certainty: We have very little confidence in the estimated effect. The true effect is likely to be substantially different from the estimated effect. a Downgraded because of imprecision due to the small sample size. b Downgraded because of a high risk of bias because the assessment was likely influenced by knowledge of intervention.
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Share and Cite

MDPI and ACS Style

Watanabe, J.; Shimamoto, J.; Kotani, K. The Effects of Antibiotics for Helicobacter pylori Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis. Antibiotics 2021, 10, 156. https://doi.org/10.3390/antibiotics10020156

AMA Style

Watanabe J, Shimamoto J, Kotani K. The Effects of Antibiotics for Helicobacter pylori Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis. Antibiotics. 2021; 10(2):156. https://doi.org/10.3390/antibiotics10020156

Chicago/Turabian Style

Watanabe, Jun, Junya Shimamoto, and Kazuhiko Kotani. 2021. "The Effects of Antibiotics for Helicobacter pylori Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis" Antibiotics 10, no. 2: 156. https://doi.org/10.3390/antibiotics10020156

APA Style

Watanabe, J., Shimamoto, J., & Kotani, K. (2021). The Effects of Antibiotics for Helicobacter pylori Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis. Antibiotics, 10(2), 156. https://doi.org/10.3390/antibiotics10020156

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop