Long Period Grating Mach–Zehnder Interferometer Based Immunosensor with Temperature and Bulk Refractive Index Compensation
Abstract
:1. Introduction
2. Methodology
2.1. Experimental Set-Ups and Signal Processing
2.2. Surface Functionalisation
2.2.1. Materials
2.2.2. Preparation Scheme
3. Results
3.1. Transmission Spectra
3.2. Temperature Measurements
3.3. External Refractive Index Measurements
3.4. IgM Measuremnts
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Platform | Measurand | IgM Concentration Range | Signal Change at the Highest Concentration | Limit of Detection | Selectivity | Reference |
---|---|---|---|---|---|---|
Long period grating | Wavelength shift | 15.6 μg/mL–1 mg/mL | ~12 nm | 15 pg/mm2 | Not stated | [3] |
Long period grating | Wavelength shift | 10 μg/mL–320 μ/mL | 4.96 nm | Not Stated | 9.4 | [23] |
LSPR on substrate | Wavelength shift | 1 μg/mL–100 μg/mL | ~1.6 nm | 1 μg/mL | ~16 | [24] |
WGM microsphere | Wavelength shift | 1 μg/mL–100 μg/mL | ~1.7 nm | 2 μg/mL | ~14.2 | [25] |
LPGMZI | Wavelength shift | 20 μg/mL-320 μg/mL | 0.39 nm | 13 μg/mL | 17.9 | This work |
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Wu, P.; Liu, L.; Morgan, S.P.; Correia, R.; Korposh, S. Long Period Grating Mach–Zehnder Interferometer Based Immunosensor with Temperature and Bulk Refractive Index Compensation. Biosensors 2022, 12, 1099. https://doi.org/10.3390/bios12121099
Wu P, Liu L, Morgan SP, Correia R, Korposh S. Long Period Grating Mach–Zehnder Interferometer Based Immunosensor with Temperature and Bulk Refractive Index Compensation. Biosensors. 2022; 12(12):1099. https://doi.org/10.3390/bios12121099
Chicago/Turabian StyleWu, Peizhou, Liangliang Liu, Stephen P. Morgan, Ricardo Correia, and Serhiy Korposh. 2022. "Long Period Grating Mach–Zehnder Interferometer Based Immunosensor with Temperature and Bulk Refractive Index Compensation" Biosensors 12, no. 12: 1099. https://doi.org/10.3390/bios12121099