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Antibacterial Activity and Cytocompatibility of Bone Cement Enriched with Antibiotic, Nanosilver, and Nanocopper for Bone Regeneration

1
Biomaterials Division, Department of Materials Engineering and Bonding, Gdańsk University of Technology, 80-233 Gdańsk, Poland
2
Chair of Clinical Biochemistry, Department of Laboratory Medicine, Medical University of Gdańsk, 80-210 Gdańsk, Poland
3
Department of Biology and Cell Imaging, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, 30-387 Kraków, Poland
4
Department of Laboratory Diagnostics and Microbiology with Blood Bank, Specialist Hospital in Kościerzyna, 83-400 Kościerzyna, Poland
5
Department of Surgical Oncologic, Medical University of Gdańsk, 80-210 Gdańsk, Poland
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(8), 1114; https://doi.org/10.3390/nano9081114
Received: 16 July 2019 / Revised: 29 July 2019 / Accepted: 30 July 2019 / Published: 3 August 2019
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Abstract

Bacterial infections due to bone replacement surgeries require modifications of bone cement with antibacterial components. This study aimed to investigate whether the incorporation of gentamicin or nanometals into bone cement may reduce and to what extent bacterial growth without the loss of overall cytocompatibility and adverse effects in vitro. The bone cement Cemex was used as the base material, modified either with gentamicin sulfate or nanometals: Silver or copper. The inhibition of bacterial adhesion and growth was examined against five different bacterial strains along with integrity of erythrocytes, viability of blood platelets, and dental pulp stem cells. Bone cement modified with nanoAg or nanoCu revealed greater bactericidal effects and prevented the biofilm formation better compared to antibiotic-loaded bone cement. The cement containing nanoAg displayed good cytocompatibility without noticeable hemolysis of erythrocytes or blood platelet disfunction and good viability of dental pulp stem cells (DPSC). On the contrary, the nanoCu cement enhanced hemolysis of erythrocytes, reduced the platelets aggregation, and decreased DPSC viability. Based on these studies, we suggest the modification of bone cement with nanoAg may be a good strategy to provide improved implant fixative for bone regeneration purposes. View Full-Text
Keywords: bone cement; nanometals; antibacterial properties; cell viability; hemolysis bone cement; nanometals; antibacterial properties; cell viability; hemolysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Wekwejt, M.; Michno, A.; Truchan, K.; Pałubicka, A.; Świeczko-Żurek, B.; Osyczka, A.M.; Zieliński, A. Antibacterial Activity and Cytocompatibility of Bone Cement Enriched with Antibiotic, Nanosilver, and Nanocopper for Bone Regeneration. Nanomaterials 2019, 9, 1114.

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