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P4VP Modified Zwitterionic Polymer for the Preparation of Antifouling Functionalized Surfaces

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, 2005 Songhu Road, Shanghai 200438, China
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(5), 706;
Received: 17 April 2019 / Revised: 26 April 2019 / Accepted: 4 May 2019 / Published: 7 May 2019
PDF [4583 KB, uploaded 7 May 2019]


Zwitterionic polymers are suitable for replacing poly(ethylene glycol) (PEG) polymers because of their better antifouling properties, but zwitterionic polymers have poor mechanical properties, strong water absorption, and their homopolymers should not be used directly. To solve these problems, a reversible-addition fragmentation chain transfer (RAFT) polymerization process was used to prepare copolymers comprised of zwitterionic side chains that were attached to an ITO glass substrate using spin-casting. The presence of 4-vinylpyridine (4VP) and zwitterion chains on these polymer-coated ITO surfaces was confirmed using 1H NMR, FTIR, and GPC analyses, with successful surface functionalization confirmed using water contact angle, X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM) studies. Changes in water contact angles and C/O ratios (XPS) analysis demonstrated that the functionalization of these polymers with β-propiolactone resulted in hydrophilic mixed 4VP/zwitterionic polymers. Protein adsorption and cell attachment assays were used to optimize the ratio of the zwitterionic component to maximize the antifouling properties of the polymer brush surface. This work demonstrated that the antifouling surface coatings could be readily prepared using a “P4VP-modified” method, that is, the functionality of P4VP to modify the prepared zwitterionic polymer. We believe these materials are likely to be useful for the preparation of biomaterials for biosensing and diagnostic applications. View Full-Text
Keywords: copolymer; biofilms; spin-casting; antifouling copolymer; biofilms; spin-casting; antifouling

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Wu, C.; Zhou, Y.; Wang, H.; Hu, J. P4VP Modified Zwitterionic Polymer for the Preparation of Antifouling Functionalized Surfaces. Nanomaterials 2019, 9, 706.

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