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Nanomaterials 2019, 9(4), 591; https://doi.org/10.3390/nano9040591

Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization

1
Department of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan 50612, Korea
2
School of Materials Science and Engineering, Pusan National University, Busan 46241, Korea
3
Department of Oral Physiology, School of Dentistry, Pusan National University, Yangsan 50612, Korea
4
Oral and Craniofacial Health Sciences Research, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
5
Department of Orthodontics, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
6
Department of Orthodontics, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Korea
7
Institute of Translational Dental Sciences, School of Dentistry, Pusan National University, Busan 49241, Korea
*
Authors to whom correspondence should be addressed.
Received: 23 February 2019 / Revised: 28 March 2019 / Accepted: 6 April 2019 / Published: 10 April 2019
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Abstract

Dentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified the effectiveness of poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass nanoparticles (MBN) ([email protected]) on DH treatment, examining the ion-releasing effect, dentin remineralization, and the occluding effect of dentinal tubules. We synthesized MBN and [email protected] After soaking each sample in simulated body fluid (SBF), we observed ion-releasing effects and dentin remineralization effects for 30 days. Also, we prepared 30 premolars to find the ratio of occluded dentinal tubules after applying MBN and [email protected], respectively. The results showed that PAMAM did not disrupt the calcium ion-releasing ability or the dentin remineralization of MBN. The [email protected] showed a better occluding effect for dentinal tubules than that of MBN (p < 0.05). In terms of dentinal tubule occlusion, the gap between MBN was well occluded due to PAMAM. This implies that [email protected] could be effectively used in dentinal tubule sealing and remineralization. View Full-Text
Keywords: PAMAM; mesoporous bioactive glass; dentin hypersensitivity; dentinal tubule occlusion PAMAM; mesoporous bioactive glass; dentin hypersensitivity; dentinal tubule occlusion
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bae, J.; Son, W.-S.; Yoo, K.-H.; Yoon, S.-Y.; Bae, M.-K.; Lee, D.J.; Ko, C.-C.; Choi, Y.-K.; Kim, Y.-I. Effects of Poly(Amidoamine) Dendrimer-Coated Mesoporous Bioactive Glass Nanoparticles on Dentin Remineralization. Nanomaterials 2019, 9, 591.

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