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Nanomaterials 2018, 8(5), 322; https://doi.org/10.3390/nano8050322

Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15

1
Institute for Biological Research “Siniša Stanković”, University of Belgrade; Bulevar Despota Stefana 142, 11060 Belgrade, Serbia
2
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany
*
Author to whom correspondence should be addressed.
Received: 7 March 2018 / Revised: 4 May 2018 / Accepted: 7 May 2018 / Published: 12 May 2018
(This article belongs to the Special Issue Pharmaceutical Nanotechnology)
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Abstract

In this study mesoporous silica SBA-15 was evaluated as a vehicle for the transport of cytotoxic natural product emodin (EO). SBA-15 was loaded with different quantities of EO (SBA-15|EO1–SBA-15|EO5: 8–36%) and characterized by traditional methods. Several parameters (stabilities) and the in vitro behavior on tumor cell lines (melanoma A375, B16 and B16F10) were investigated. SBA-15 suppresses EO release in extremely acidic milieu, pointing out that EO will not be discharged in the stomach. Furthermore, SBA-15 protects EO from photodecomposition. In vitro studies showed a dose dependent decrease of cellular viability which is directly correlated with an increasing amount of EO in SBA-15 for up to 27% of EO, while a constant activity for 32% and 36% of EO in SBA-15 was observed. Additionally, SBA-15 loaded with EO (SBA-15|EO3) does not disturb viability of peritoneal macrophages. SBA-15|EO3 causes inhibition of tumor cell proliferation and triggers apoptosis, connected with caspase activation, upregulation of Bax, as well as Bcl-2 and Bim downregulation along with amplification of poly-(ADP-ribose)-polymerase (PARP) cleavage fragment. Thus, the mesoporous SBA-15 is a promising carrier of the water-insoluble drug emodin. View Full-Text
Keywords: emodin; SBA-15; apoptosis; autophagy; melanoma emodin; SBA-15; apoptosis; autophagy; melanoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Krajnović, T.; Maksimović-Ivanić, D.; Mijatović, S.; Drača, D.; Wolf, K.; Edeler, D.; Wessjohann, L.A.; Kaluđerović, G.N. Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15. Nanomaterials 2018, 8, 322.

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