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Nanomaterials 2018, 8(5), 319;

Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease

Dipartimento di Matematica e Fisica “E. De Giorgi”, Università del Salento, Via Monteroni, 73100 Lecce, Italy
Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi di Bari “Aldo Moro”, p.zza G. Cesare, 70124 c/o Policlinico Bari, Italy
CNR Nanotec-Istituto di Nanotecnologia, c/o Campus Ecotekne, Via Monteroni, 73100 Lecce, Italy
Authors to whom correspondence should be addressed.
Received: 24 April 2018 / Revised: 7 May 2018 / Accepted: 8 May 2018 / Published: 10 May 2018
(This article belongs to the Special Issue Nanocolloids for Nanomedicine and Drug Delivery)
PDF [4219 KB, uploaded 10 May 2018]


The large use of nanomaterials in many fields of application and commercial products highlights their potential toxicity on living organisms and the environment, despite their physico-chemical properties. Among these, silver nanoparticles (Ag NPs) are involved in biomedical applications such as antibacterial agents, drug delivery vectors and theranostics agents. In this review, we explain the common synthesis routes of Ag NPs using physical, chemical, and biological methods, following their toxicity mechanism in cells. In particular, we analyzed the physiological cellular pathway perturbations in terms of oxidative stress induction, mitochondrial membrane potential alteration, cell death, apoptosis, DNA damage and cytokines secretion after Ag NPs exposure. In addition, their potential anti-cancer activity and theranostic applications are discussed. View Full-Text
Keywords: silver nanoparticles; synthetic routes; toxicity; theranostics silver nanoparticles; synthetic routes; toxicity; theranostics

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De Matteis, V.; Cascione, M.; Toma, C.C.; Leporatti, S. Silver Nanoparticles: Synthetic Routes, In Vitro Toxicity and Theranostic Applications for Cancer Disease. Nanomaterials 2018, 8, 319.

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