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Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA

Center for Bio-Artificial Muscle and Department of Biomedical Engineering, Hanyang University, Seoul 04763, Korea
Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Department of Biomedical Engineering, Izmir Katip Celebi University, Izmir 35620, Turkey
Korea Packaging Center, Korea Institute of Industrial Technology, Bucheon 14449, Korea
Department of Metallurgical and Materials Engineering, Eskisehir Osmangazi University, Eskisehir 26040, Turkey
KU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea
Future Environmental Research Center, Korea Institute of Toxicology, Jinju 52834, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2018, 8(4), 226;
Received: 6 March 2018 / Revised: 28 March 2018 / Accepted: 1 April 2018 / Published: 8 April 2018
PDF [19965 KB, uploaded 3 May 2018]


The unique biological features of supramolecular DNA have led to an increasing interest in biomedical applications such as biosensors. We have developed an i-motif and G-rich DNA conjugated single-walled carbon nanotube hybrid materials, which shows reversible conformational switching upon external stimuli such as pH (5 and 8) and presence of ions (Li+ and K+). We observed reversible electrochemical redox activity upon external stimuli in a quick and robust manner. Given the ease and the robustness of this method, we believe that pH- and ion-driven reversible DNA structure transformations will be utilized for future applications for developing novel biosensors. View Full-Text
Keywords: carbon nanotube; DNA; biosensor carbon nanotube; DNA; biosensor

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chang, S.; Kilic, T.; Lee, C.K.; Avci, H.; Bae, H.; Oskui, S.M.; Jung, S.M.; Shin, S.R.; Kim, S.J. Reversible Redox Activity by Ion-pH Dually Modulated Duplex Formation of i-Motif DNA with Complementary G-DNA. Nanomaterials 2018, 8, 226.

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