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Nanomaterials 2017, 7(5), 94;

Recent Advances in Nanomaterials for Gene Delivery—A Review

Graduate Program in Plant Cellular and Molecular Biology, University of Florida, Gainesville, FL 32611, USA
UF Genetics Institute, University of Florida, Gainesville, FL 32611, USA
Department of Microbiology & Cell Science, University of Florida, Cancer/Genetics Research Complex 302, 2033 Mowry Road, Gainesville, FL 32610, USA
Author to whom correspondence should be addressed.
Academic Editor: Fani Sousa
Received: 16 March 2017 / Revised: 20 April 2017 / Accepted: 24 April 2017 / Published: 28 April 2017
(This article belongs to the Special Issue Nanomaterials in Gene Therapy)
PDF [2445 KB, uploaded 28 April 2017]


With the rapid development of nanotechnology in the recent decade, novel DNA and RNA delivery systems for gene therapy have become available that can be used instead of viral vectors. These non-viral vectors can be made of a variety of materials, including inorganic nanoparticles, carbon nanotubes, liposomes, protein and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have as advantages over viral vectors a decreased immune response, and additionally offer flexibility in design, allowing them to be functionalized and targeted to specific sites in a biological system with low cytotoxicity. The focus of this review is to provide an overview of novel nanotechnology-based methods to deliver DNA and small interfering RNAs into biological systems. View Full-Text
Keywords: gene delivery; nanomaterials; non-viral vectors; siRNA gene delivery; nanomaterials; non-viral vectors; siRNA

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Riley, M.K., II; Vermerris, W. Recent Advances in Nanomaterials for Gene Delivery—A Review. Nanomaterials 2017, 7, 94.

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