Next Article in Journal
Increased Efficiency of Solar Cells Protected by Hydrophobic and Hydrophilic Anti-Reflecting Nanostructured Glasses
Previous Article in Journal
Morphological and Optical Characteristics of Chitosan(1−x):Cuox (4 ≤ x ≤ 12) Based Polymer Nano-Composites: Optical Dielectric Loss as an Alternative Method for Tauc’s Model
Open AccessArticle

Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release

National R-D Institute for Chemistry and Petrochemistry ICECHIM—Bucharest, Spl. Independentei 202, 6th district, P.O. Box 35/174, 060021 Bucharest, Romania
Institute of Physical Chemistry “Ilie Murgulescu”, Romanian Academy, Spl. Independentei 202, 6th district, P.O. Box 194, 060021 Bucharest, Romania
Institute of Biochemistry of the Romanian Academy, Ligand-Receptor Interaction Department, Spl. Independentei 296, 060031 Bucharest 17, Romania
Authors to whom correspondence should be addressed.
Nanomaterials 2017, 7(12), 443;
Received: 31 October 2017 / Revised: 24 November 2017 / Accepted: 8 December 2017 / Published: 13 December 2017
Present study refers to the synthesis of new advanced materials based on poly(methacrylic acid) (PMAA) with previously reported own advanced modified clays by edge covalent bonding. This will create the premises to obtain nanocomposite hydrogels with combined hydrophilic-hydrophobic behavior absolutely necessary for co-delivery of polar/nonpolar substances. For the synthesis, N,N’-methylenebisacrylamide was used as cross-linker and ammonium persulphate as initiator. As a consequence of the inclusion of clay into the polymer matrix and the intercalation of PMAA between the layers as well as the presence of hydrophobic interactions occurred between partners, the final hydrogel nanocomposites possessed greater swelling degrees, slower de-swelling process and enhanced mechanical properties depending on the clay type in comparison with pure hydrogel. In vitro MTS ([3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt]) colorimetric assay showed that direct exposure with PMMA-clay-based constructs did not affect cell viability and proliferation in time (24 and 48 h) on either normal or adenocarcinoma cell lines. View Full-Text
Keywords: hydrogel; clay; nanocomposites; biocompatibility hydrogel; clay; nanocomposites; biocompatibility
Show Figures

Graphical abstract

MDPI and ACS Style

Ianchis, R.; Ninciuleanu, C.M.; Gifu, I.C.; Alexandrescu, E.; Somoghi, R.; Gabor, A.R.; Preda, S.; Nistor, C.L.; Nitu, S.; Petcu, C.; Icriverzi, M.; Florian, P.E.; Roseanu, A.M. Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release. Nanomaterials 2017, 7, 443.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop