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Open AccessArticle

Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus

1
Department of Food and Nutrition, Chosun University, Gwangju 61452, Korea
2
Institute of Biomaterials, Kwangwoon University, 20 Kwangwoongil, Nowon-gu, Seoul 01897, Korea
3
Halla Energy and Environment, Seoul 05769, Korea
4
Department of Chemistry, Chosun University, Gwangju 61452, Korea
5
College of Pharmacy, Chosun University, Gwangju 61452, Korea
6
Department of Electrical & Biological Physics, Kwangwoon University, 20 Kwangwoongil, Nowon-gu, Seoul 01897, Korea
*
Authors to whom correspondence should be addressed.
Nanomaterials 2017, 7(11), 365; https://doi.org/10.3390/nano7110365
Received: 30 September 2017 / Revised: 29 October 2017 / Accepted: 31 October 2017 / Published: 2 November 2017
(This article belongs to the Special Issue Frontiers in Toxicity and Functionalization of Nanomaterials)
In this study, we report a new multifunctional nanoparticle with antioxidative and antibacterial activities in vitro. [email protected] nanoparticles were fabricated by coordinated covalent bonding of the antioxidant gallic acid (GA) on the surface of ZnO nanoparticles. This addition imparts both antioxidant activity and high affinity for the bacterial cell membrane. Antioxidative activities at various concentrations were evaluated using a 2,2′-azino-bis(ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging method. Antibacterial activities were evaluated against Gram-positive bacteria (Staphylococcus aureus: S. aureus), including several strains of methicillin-resistant S. aureus (MRSA), and Gram-negative bacteria (Escherichia coli). The functionalized [email protected] nanoparticles showed good antioxidative activity (69.71%), and the bactericidal activity of these nanoparticles was also increased compared to that of non-functionalized ZnO nanoparticles, with particularly effective inhibition and high selectivity for MRSA strains. The results indicate that multifunctional ZnO nanoparticles conjugated to GA molecules via a simple surface modification process displaying both antioxidant and antibacterial activity, suggesting a possibility to use it as an antibacterial agent for removing MRSA. View Full-Text
Keywords: [email protected]; antioxidative activity; antibacterial activity; gallic acid; antibiotic resistance; methicillin-resistant Staphylococcus aureus [email protected]; antioxidative activity; antibacterial activity; gallic acid; antibiotic resistance; methicillin-resistant Staphylococcus aureus
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Lee, J.; Choi, K.-H.; Min, J.; Kim, H.-J.; Jee, J.-P.; Park, B.J. Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus. Nanomaterials 2017, 7, 365.

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