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Open AccessReview

Nano-Biosensor for Monitoring the Neural Differentiation of Stem Cells

by Jin-Ho Lee 1,2,†, Taek Lee 1,2,† and Jeong-Woo Choi 1,2,*
1
Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul 121-742, Korea
2
Institute of Integrated Biotechnology, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul 121-742, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Chen-Zhong Li and Ling-Jie Meng
Nanomaterials 2016, 6(12), 224; https://doi.org/10.3390/nano6120224
Received: 6 July 2016 / Revised: 7 November 2016 / Accepted: 17 November 2016 / Published: 28 November 2016
(This article belongs to the Special Issue Nanostructured Biosensors 2016)
In tissue engineering and regenerative medicine, monitoring the status of stem cell differentiation is crucial to verify therapeutic efficacy and optimize treatment procedures. However, traditional methods, such as cell staining and sorting, are labor-intensive and may damage the cells. Therefore, the development of noninvasive methods to monitor the differentiation status in situ is highly desirable and can be of great benefit to stem cell-based therapies. Toward this end, nanotechnology has been applied to develop highly-sensitive biosensors to noninvasively monitor the neural differentiation of stem cells. Herein, this article reviews the development of noninvasive nano-biosensor systems to monitor the neural differentiation of stem cells, mainly focusing on optical (plasmonic) and eletrochemical methods. The findings in this review suggest that novel nano-biosensors capable of monitoring stem cell differentiation are a promising type of technology that can accelerate the development of stem cell therapies, including regenerative medicine. View Full-Text
Keywords: biosensor; neural differentiation; stem cell; nanostructure; optical detection method; electrochemical detection method biosensor; neural differentiation; stem cell; nanostructure; optical detection method; electrochemical detection method
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Lee, J.-H.; Lee, T.; Choi, J.-W. Nano-Biosensor for Monitoring the Neural Differentiation of Stem Cells. Nanomaterials 2016, 6, 224.

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