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Simultaneous Detection of Dopamine and Uric Acid Using a Poly(l-lysine)/Graphene Oxide Modified Electrode

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
School of Chemistry and Chemical Engineering, Nantong University, Nantong 226007, China
Authors to whom correspondence should be addressed.
Academic Editor: Jianbo Wu
Nanomaterials 2016, 6(10), 178;
Received: 29 July 2016 / Revised: 4 September 2016 / Accepted: 12 September 2016 / Published: 28 September 2016
(This article belongs to the Special Issue Nanomaterials for Electrocatalysis)
PDF [8919 KB, uploaded 28 September 2016]


A novel, simple and selective electrochemical method was investigated for the simultaneous detection of dopamine (DA) and uric acid (UA) on a poly(l-lysine)/graphene oxide (GO) modified glassy carbon electrode (PLL/GO/GCE) by differential pulse voltammetry (DPV). The electrochemically prepared PLL/GO sensory platform toward the oxidation of UA and DA exhibited several advantages, including high effective surface area, more active sites and enhanced electrochemical activity. Compared to the PLL-modified GCE (PLL/GCE), GO-modified GCE and bare GCE, the PLL/GO/GCE exhibited an increase in the anodic potential difference and a remarkable enhancement in the current responses for both UA and DA. For the simultaneous detection of DA and UA, the detection limits of 0.021 and 0.074 μM were obtained, while 0.031 and 0.018 μM were obtained as the detection limits for the selective detection of UA and DA, using DPV in the linear concentration ranges of 0.5 to 20.0 and 0.5 to 35 μM, respectively. In addition, the PLL/GO/GCE demonstrated good reproducibility, long-term stability, excellent selectivity and negligible interference of ascorbic acid (AA). The proposed modified electrode was successfully implemented in the simultaneous detection of DA and UA in human blood serum, urine and dopamine hydrochloride injection with satisfactory results. View Full-Text
Keywords: graphene oxide; poly(l-lysine); dopamine; uric acid; simultaneous determination graphene oxide; poly(l-lysine); dopamine; uric acid; simultaneous determination

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhang, Y.; Lei, W.; Xu, Y.; Xia, X.; Hao, Q. Simultaneous Detection of Dopamine and Uric Acid Using a Poly(l-lysine)/Graphene Oxide Modified Electrode. Nanomaterials 2016, 6, 178.

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