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Nanomaterials 2012, 2(3), 275-285;

Assembly of DNA Architectures in a Non-Aqueous Solution

RDRL-SEE-B, Adelphi, MD 20783, USA
Episensors, Inc., 590 Territorial Drive, Bolingbrook, IL 60440, USA
Author to whom correspondence should be addressed.
Received: 18 June 2012 / Revised: 8 August 2012 / Accepted: 20 August 2012 / Published: 31 August 2012
(This article belongs to the Special Issue Trends of Nanomaterials in Life Sciences)
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In the present work, the procedures for the creation of self-assembled DNA nanostructures in aqueous and non-aqueous media are described. DNA-Surfactant complex formation renders the DNA soluble in organic solvents offering an exciting way to bridge the transition of DNA origami materials electronics applications. The DNA retains its structural features, and these unique geometries provide an interesting candidate for future electronics and nanofabrication applications with potential for new properties. The DNA architectures were first assembled under aqueous conditions, and then characterized in solution (using circular dichroism (CD) spectroscopy) and on the surface (using atomic force microscopy (AFM)). Following aqueous assembly, the DNA nanostructures were transitioned to a non-aqueous environment, where butanol was chosen for optical compatibility and thermal properties. The retention of DNA hierarchical structure and thermal stability in non-aqueous conditions were confirmed via CD spectroscopy. The formation and characterization of these higher order DNA-surfactant complexes is described in this paper. View Full-Text
Keywords: DNA nanostructures; bioelectronics; biodirected assembly; CTAC; DNA DNA nanostructures; bioelectronics; biodirected assembly; CTAC; DNA

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Finch, A.S.; Anton, C.M.; Jacob, C.M.; Proctor, T.J.; Stratis-Cullum, D.N. Assembly of DNA Architectures in a Non-Aqueous Solution. Nanomaterials 2012, 2, 275-285.

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