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Review

State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications

College of Textiles & Clothing, Qingdao University, Qingdao 266071, China
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Academic Editors: Rosalia Bertorelli and Takuya Kitaoka
Nanomaterials 2022, 12(5), 784; https://doi.org/10.3390/nano12050784
Received: 21 January 2022 / Revised: 22 February 2022 / Accepted: 25 February 2022 / Published: 25 February 2022
Electrospun nanofiber materials have been considered as advanced dressing candidates in the perspective of wound healing and skin regeneration, originated from their high porosity and permeability to air and moisture, effective barrier performance of external pathogens, and fantastic extracellular matrix (ECM) fibril mimicking property. Gelatin is one of the most important natural biomaterials for the design and construction of electrospun nanofiber-based dressings, due to its excellent biocompatibility and biodegradability, and great exudate-absorbing capacity. Various crosslinking approaches including physical, chemical, and biological methods have been introduced to improve the mechanical stability of electrospun gelatin-based nanofiber mats. Some innovative electrospinning strategies, including blend electrospinning, emulsion electrospinning, and coaxial electrospinning, have been explored to improve the mechanical, physicochemical, and biological properties of gelatin-based nanofiber mats. Moreover, numerous bioactive components and therapeutic agents have been utilized to impart the electrospun gelatin-based nanofiber dressing materials with multiple functions, such as antimicrobial, anti-inflammation, antioxidation, hemostatic, and vascularization, as well as other healing-promoting capacities. Noticeably, electrospun gelatin-based nanofiber mats integrated with specific functions have been fabricated to treat some hard-healing wound types containing burn and diabetic wounds. This work provides a detailed review of electrospun gelatin-based nanofiber dressing materials without or with therapeutic agents for wound healing and skin regeneration applications. View Full-Text
Keywords: electrospinning; gelatin; nanofiber; wound dressing; skin regeneration electrospinning; gelatin; nanofiber; wound dressing; skin regeneration
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MDPI and ACS Style

Li, T.; Sun, M.; Wu, S. State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications. Nanomaterials 2022, 12, 784. https://doi.org/10.3390/nano12050784

AMA Style

Li T, Sun M, Wu S. State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications. Nanomaterials. 2022; 12(5):784. https://doi.org/10.3390/nano12050784

Chicago/Turabian Style

Li, Tao, Mingchao Sun, and Shaohua Wu. 2022. "State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications" Nanomaterials 12, no. 5: 784. https://doi.org/10.3390/nano12050784

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