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Review

Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

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Department of Chemical Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates
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The Material Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah P.O. BOX 26666, United Arab Emirates
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Authors to whom correspondence should be addressed.
Academic Editor: Alexandru Mihai Grumezescu
Nanomaterials 2022, 12(2), 277; https://doi.org/10.3390/nano12020277
Received: 12 December 2021 / Revised: 7 January 2022 / Accepted: 11 January 2022 / Published: 16 January 2022
Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems. View Full-Text
Keywords: metal−organic frameworks; disease diagnosis; drug delivery; theranostic agent metal−organic frameworks; disease diagnosis; drug delivery; theranostic agent
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MDPI and ACS Style

Al Sharabati, M.; Sabouni, R.; Husseini, G.A. Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review. Nanomaterials 2022, 12, 277. https://doi.org/10.3390/nano12020277

AMA Style

Al Sharabati M, Sabouni R, Husseini GA. Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review. Nanomaterials. 2022; 12(2):277. https://doi.org/10.3390/nano12020277

Chicago/Turabian Style

Al Sharabati, Miral, Rana Sabouni, and Ghaleb A. Husseini. 2022. "Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review" Nanomaterials 12, no. 2: 277. https://doi.org/10.3390/nano12020277

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