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Open AccessArticle

Signal-On Fluorescent Imprinted Nanoparticles for Sensing of Phenols in Aqueous Olive Leaves Extracts

Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, via Giorgieri 1, 34127 Trieste, Italy
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Nanomaterials 2020, 10(6), 1011; https://doi.org/10.3390/nano10061011
Received: 19 April 2020 / Revised: 18 May 2020 / Accepted: 22 May 2020 / Published: 26 May 2020
(This article belongs to the Section Synthesis, Interfaces and Nanostructures)
The activation of signals in fluorescent nanosensors upon interaction with their targets is highly desirable. To this aim, several molecularly imprinted nanogels have been synthetized for the recognition of tyrosol, hydroxytyrosol and oleuropein in aqueous extracts using the non-covalent approach. Two of them contain fluorescein derivatives as co-monomers, and their fluorescence emission is switched on upon binding of the target phenols. The selection of functional monomers was previously done by analyzing the interactions by nuclear magnetic resonance (NMR) in deuterated dimethylsulfoxide (DMSO-d6) of the monomers with tyrosol and hydroxytyrosol. Polymers were synthetized under high dilution conditions to obtain micro- and nano-particles, as verified by transmission electron microscopy (TEM). 1,4-Divinylbenzene (DVB) was used in the fluorescent polymers in order to enhance the interactions with the aromatic ring of the templates tyrosol and hydroxytyrosol by π-π stacking. The results were fully satisfactory as to rebinding: DVB-crosslinked molecularly imprinted polymers (MIPs) gave over 50 nmol/mg rebinding. The sensitivity of the fluorescent MIPs was excellent, with LODs in the pM range. The sensing polymers were tested on real olive leaves extracts, with very good performance and negligible matrix effects. View Full-Text
Keywords: imprinted nanogel; phenols; fluorescence; olive leaf extracts imprinted nanogel; phenols; fluorescence; olive leaf extracts
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MDPI and ACS Style

Stavro Santarosa, A.; Berti, F.; Tommasini, M.; Calabretti, A.; Forzato, C. Signal-On Fluorescent Imprinted Nanoparticles for Sensing of Phenols in Aqueous Olive Leaves Extracts. Nanomaterials 2020, 10, 1011. https://doi.org/10.3390/nano10061011

AMA Style

Stavro Santarosa A, Berti F, Tommasini M, Calabretti A, Forzato C. Signal-On Fluorescent Imprinted Nanoparticles for Sensing of Phenols in Aqueous Olive Leaves Extracts. Nanomaterials. 2020; 10(6):1011. https://doi.org/10.3390/nano10061011

Chicago/Turabian Style

Stavro Santarosa, Ada; Berti, Federico; Tommasini, Martina; Calabretti, Antonella; Forzato, Cristina. 2020. "Signal-On Fluorescent Imprinted Nanoparticles for Sensing of Phenols in Aqueous Olive Leaves Extracts" Nanomaterials 10, no. 6: 1011. https://doi.org/10.3390/nano10061011

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