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J. Funct. Biomater. 2017, 8(4), 46;

Fe Core–Carbon Shell Nanoparticles as Advanced MRI Contrast Enhancer

Department of Physics, University of Texas at Arlington; Arlington, TX 76019, USA
Advanced Imaging Research Center, Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
NanoScope Technologies LLC, Bedford, TX 76022, USA
Author to whom correspondence should be addressed.
Academic Editor: Stefan H. Bossmann
Received: 22 April 2017 / Revised: 8 September 2017 / Accepted: 29 September 2017 / Published: 9 October 2017
(This article belongs to the Special Issue Magnetic Nanoparticle Design for Medical Diagnosis and Therapy)
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The aim of this study is to fabricate a hybrid composite of iron (Fe) core–carbon (C) shell nanoparticles with enhanced magnetic properties for contrast enhancement in magnetic resonance imaging (MRI). These new classes of magnetic core–shell nanoparticles are synthesized using a one-step top–down approach through the electric plasma discharge generated in the cavitation field in organic solvents by an ultrasonic horn. Transmission electron microscopy (TEM) observations revealed the core–shell nanoparticles with 10–85 nm in diameter with excellent dispersibility in water without any agglomeration. TEM showed the structural confirmation of Fe nanoparticles with body centered cubic (bcc) crystal structure. Magnetic multi-functional hybrid composites of Fe core–C shell nanoparticles were then evaluated as negative MRI contrast agents, displaying remarkably high transverse relaxivity (r2) of 70 mM−1·S−1 at 7 T. This simple one-step synthesis procedure is highly versatile and produces desired nanoparticles with high efficacy as MRI contrast agents and potential utility in other biomedical applications. View Full-Text
Keywords: MRI; contrast agent; superparamagnetic; core-shell nanoparticles MRI; contrast agent; superparamagnetic; core-shell nanoparticles

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Chaudhary, R.P.; Kangasniemi, K.; Takahashi, M.; Mohanty, S.K.; Koymen, A.R. Fe Core–Carbon Shell Nanoparticles as Advanced MRI Contrast Enhancer. J. Funct. Biomater. 2017, 8, 46.

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