Next Article in Journal
The Anti-Inflammatory and Vasodilating Effects of Three Selected Dietary Organic Sulfur Compounds from Allium Species
Next Article in Special Issue
Atomic Force Microscopy: A Powerful Tool to Address Scaffold Design in Tissue Engineering
Previous Article in Journal
Minimizing Skin Scarring through Biomaterial Design
Previous Article in Special Issue
Debris Evaluation after Root Canal Shaping with Rotating and Reciprocating Single-File Systems
Open AccessArticle

Bioactive Polymeric Materials for Tissue Repair

Volpe Research Center, ADA Foundation, Gaithersburg, MD 20899, USA
Food and Drug Administration, Silver Spring, MD 20993, USA
Author to whom correspondence should be addressed.
Academic Editor: Francesco Puoci
J. Funct. Biomater. 2017, 8(1), 4;
Received: 10 November 2016 / Revised: 10 January 2017 / Accepted: 18 January 2017 / Published: 26 January 2017
(This article belongs to the Special Issue Journal of Functional Biomaterials: Feature Papers 2016)
Bioactive polymeric materials based on calcium phosphates have tremendous appeal for hard tissue repair because of their well-documented biocompatibility. Amorphous calcium phosphate (ACP)-based ones additionally protect against unwanted demineralization and actively support regeneration of hard tissue minerals. Our group has been investigating the structure/composition/property relationships of ACP polymeric composites for the last two decades. Here, we present ACP’s dispersion in a polymer matrix and the fine-tuning of the resin affects the physicochemical, mechanical, and biological properties of ACP polymeric composites. These studies illustrate how the filler/resin interface and monomer/polymer molecular structure affect the material’s critical properties, such as ion release and mechanical strength. We also present evidence of the remineralization efficacy of ACP composites when exposed to accelerated acidic challenges representative of oral environment conditions. The utility of ACP has recently been extended to include airbrushing as a platform technology for fabrication of nanofiber scaffolds. These studies, focused on assessing the feasibility of incorporating ACP into various polymer fibers, also included the release kinetics of bioactive calcium and phosphate ions from nanofibers and evaluate the biorelevance of the polymeric ACP fiber networks. We also discuss the potential for future integration of the existing ACP scaffolds into therapeutic delivery systems used in the precision medicine field. View Full-Text
Keywords: airbrushing; blow spinning; amorphous calcium phosphate; bone repair; cell/fiber interactions; nanofibers; remineralizing polymeric composite airbrushing; blow spinning; amorphous calcium phosphate; bone repair; cell/fiber interactions; nanofibers; remineralizing polymeric composite
Show Figures

Figure 1

MDPI and ACS Style

Bienek, D.R.; Tutak, W.; Skrtic, D. Bioactive Polymeric Materials for Tissue Repair. J. Funct. Biomater. 2017, 8, 4.

AMA Style

Bienek DR, Tutak W, Skrtic D. Bioactive Polymeric Materials for Tissue Repair. Journal of Functional Biomaterials. 2017; 8(1):4.

Chicago/Turabian Style

Bienek, Diane R.; Tutak, Wojtek; Skrtic, Drago. 2017. "Bioactive Polymeric Materials for Tissue Repair" J. Funct. Biomater. 8, no. 1: 4.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop