Next Article in Journal
Replacing the Transfusion of 1–2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies
Previous Article in Journal
The Effect of Chondroitin Sulphate and Hyaluronic Acid on Chondrocytes Cultured within a Fibrin-Alginate Hydrogel
Article

Synthesis and Characterization of Fatty Acid/Amino Acid Self-Assemblies

1
Department of Biomaterials and Microbiological Technologies, The West Pomeranian University of Technology, Szczecin, Al. Piastow 45, 70-311 Szczecin, Poland
2
New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2014, 5(4), 211-231; https://doi.org/10.3390/jfb5040211
Received: 21 June 2014 / Revised: 19 September 2014 / Accepted: 26 September 2014 / Published: 24 October 2014
In this paper, we discuss the synthesis and self-assembling behavior of new copolymers derived from fatty acid/amino acid components, namely dimers of linoleic acid (DLA) and tyrosine derived diphenols containing alkyl ester pendent chains, designated as “R” (DTR). Specific pendent chains were ethyl (E) and hexyl (H). These poly(aliphatic/aromatic-ester-amide)s were further reacted with poly(ethylene glycol) (PEG) and poly(ethylene glycol methyl ether) of different molecular masses, thus resulting in ABA type (hydrophilic-hydrophobic-hydrophilic) triblock copolymers. We used Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies to evaluate the chemical structure of the final materials. The molecular masses were estimated by gel permeation chromatography (GPC) measurements. The self-organization of these new polymeric systems into micellar/nanospheric structures in aqueous environment was evaluated using ultraviolet/visible (UV-VIS) spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). The polymers were found to spontaneously self-assemble into nanoparticles with sizes in the range 196–239 nm and critical micelle concentration (CMC) of 0.125–0.250 mg/mL. The results are quite promising and these materials are capable of self-organizing into well-defined micelles/nanospheres encapsulating bioactive molecules, e.g., vitamins or antibacterial peptides for antibacterial coatings on medical devices. View Full-Text
Keywords: amphiphilic block copolymers; fatty acid; micelle amphiphilic block copolymers; fatty acid; micelle
Show Figures

Figure 1

MDPI and ACS Style

Gajowy, J.; Bolikal, D.; Kohn, J.; Fray, M.E. Synthesis and Characterization of Fatty Acid/Amino Acid Self-Assemblies. J. Funct. Biomater. 2014, 5, 211-231. https://doi.org/10.3390/jfb5040211

AMA Style

Gajowy J, Bolikal D, Kohn J, Fray ME. Synthesis and Characterization of Fatty Acid/Amino Acid Self-Assemblies. Journal of Functional Biomaterials. 2014; 5(4):211-231. https://doi.org/10.3390/jfb5040211

Chicago/Turabian Style

Gajowy, Joanna, Durgadas Bolikal, Joachim Kohn, and Miroslawa E. Fray. 2014. "Synthesis and Characterization of Fatty Acid/Amino Acid Self-Assemblies" Journal of Functional Biomaterials 5, no. 4: 211-231. https://doi.org/10.3390/jfb5040211

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop