Next Article in Journal
Development of a More Environmentally Friendly Silk Fibroin Scaffold for Soft Tissue Applications
Previous Article in Journal
Immunomodulatory Effects Mediated by Nano Amorphous Calcium Phosphate/Chitosan Oligosaccharide Lactate Coatings Decorated with Selenium on Titanium Implants
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JFB
Volume 14
Issue 4
10.3390/jfb14040229
jfb-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Investigation of the Biosafety of Antibacterial Mg(OH)2 Nanoparticles to a Normal Biological System

by
Ying Wang
1,*,
Yanjing Liu
1,
Xiyue Li
1,
Fuming Wang
1,
Yaping Huang
1,
Yuezhou Liu
1 and
Yimin Zhu
2,*
1
School of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034, China
2
Collaborative Innovation Central for Vessel Pollution Monitoring and Control, Dalian Maritime University, Dalian 116026, China
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2023, 14(4), 229; https://doi.org/10.3390/jfb14040229
Submission received: 20 February 2023 / Revised: 21 March 2023 / Accepted: 14 April 2023 / Published: 18 April 2023
(This article belongs to the Section Antibacterial Biomaterials)
Browse Figures
Review Reports Versions Notes

Abstract

The toxicity of Mg(OH)2 nanoparticles (NPs) as antibacterial agents to a normal biological system is unclear, so it is necessary to evaluate their potential toxic effect for safe use. In this work, the administration of these antibacterial agents did not induce pulmonary interstitial fibrosis as no significant effect on the proliferation of HELF cells was observed in vitro. Additionally, Mg(OH)2 NPs caused no inhibition of the proliferation of PC-12 cells, indicating that the brain’s nervous system was not affected by Mg(OH)2 NPs. The acute oral toxicity test showed that the Mg(OH)2 NPs at 10,000 mg/kg induced no mortality during the administration period, and there was little toxicity in vital organs according to a histological analysis. In addition, the in vivo acute eye irritation test results showed little acute irritation of the eye caused by Mg(OH)2 NPs. Thus, Mg(OH)2 NPs exhibited great biosafety to a normal biological system, which was critical for human health and environmental protection.
Keywords: biosafety; Mg(OH)2 NPs; toxicity; irritation; cytotoxicity biosafety; Mg(OH)2 NPs; toxicity; irritation; cytotoxicity

Share and Cite

MDPI and ACS Style

Wang, Y.; Liu, Y.; Li, X.; Wang, F.; Huang, Y.; Liu, Y.; Zhu, Y. Investigation of the Biosafety of Antibacterial Mg(OH)2 Nanoparticles to a Normal Biological System. J. Funct. Biomater. 2023, 14, 229. https://doi.org/10.3390/jfb14040229

AMA Style

Wang Y, Liu Y, Li X, Wang F, Huang Y, Liu Y, Zhu Y. Investigation of the Biosafety of Antibacterial Mg(OH)2 Nanoparticles to a Normal Biological System. Journal of Functional Biomaterials. 2023; 14(4):229. https://doi.org/10.3390/jfb14040229

Chicago/Turabian Style

Wang, Ying, Yanjing Liu, Xiyue Li, Fuming Wang, Yaping Huang, Yuezhou Liu, and Yimin Zhu. 2023. "Investigation of the Biosafety of Antibacterial Mg(OH)2 Nanoparticles to a Normal Biological System" Journal of Functional Biomaterials 14, no. 4: 229. https://doi.org/10.3390/jfb14040229

APA Style

Wang, Y., Liu, Y., Li, X., Wang, F., Huang, Y., Liu, Y., & Zhu, Y. (2023). Investigation of the Biosafety of Antibacterial Mg(OH)2 Nanoparticles to a Normal Biological System. Journal of Functional Biomaterials, 14(4), 229. https://doi.org/10.3390/jfb14040229

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop