Next Article in Journal
Complex Modeling and Design of Catalytic Reactors Using Multiscale Approach—Part 1: Diffusion in Porous Catalyst
Previous Article in Journal
An Incompressible Smoothed Particle Hydrodynamics (ISPH) Model of Direct Laser Interference Patterning
Article

Targeted Drug Delivery of Magnetic Nano-Particle in the Specific Lung Region

1
School of Chemistry, Physics & Mechanical Engineering, Queensland University of Technology (QUT), 2 George Street, GPO Box 2434, Brisbane, QLD 4001, Australia
2
School of Mechanical and Mechatronic Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Ultimo, New South Wales 2007, Australia
*
Author to whom correspondence should be addressed.
Computation 2020, 8(1), 10; https://doi.org/10.3390/computation8010010
Received: 8 January 2020 / Revised: 24 January 2020 / Accepted: 27 January 2020 / Published: 4 February 2020
(This article belongs to the Section Computational Engineering)
Aerosolized drug inhalation plays an important role in the treatment of respiratory diseases. All of the published in silico, in vivo, and in vitro studies have improved the knowledge of aerosol delivery in the human respiratory system. However, aerosolized magnetic nano-particle (MNP) transport and deposition (TD) for the specific position of the human lung are still unavailable in the literature. Therefore, this study is aimed to provide an understanding of the magnetic nano-particle TD in the targeted region by imposing an external magnetic field for the development of future therapeutics. Uniform aerosolized nano-particle TD in the specific position of the lung airways will be modelled by adopting turbulence k–ω low Reynolds number simulation. The Euler–Lagrange (E–L) approach and the magneto hydrodynamics (MHD) model are incorporated in the ANSYS fluent (18.0) solver to investigate the targeted nano-particle TD. The human physical activity conditions of sleeping, resting, light activity and fast breathing are considered in this study. The aerosolized drug particles are navigated to the targeted position under the influence of external magnetic force (EMF), which is applied in two different positions of the two-generation lung airways. A numerical particle tracing model is also developed to predict the magnetic drug targeting behavior in the lung. The numerical results reveal that nano-particle deposition efficiency (DE) in two different magnetic field position is different for various physical activities, which could be helpful for targeted drug delivery to a specific region of the lung after extensive clinical trials. This process will also be cost-effective and will minimize unwanted side effects due to systemic drug distribution in the lung. View Full-Text
Keywords: pharmaceutical aerosol; magnetic field; magnetic number; targeted drug delivery; magneto hydrodynamics pharmaceutical aerosol; magnetic field; magnetic number; targeted drug delivery; magneto hydrodynamics
Show Figures

Figure 1

MDPI and ACS Style

Ghosh, A.; Islam, M.S.; Saha, S.C. Targeted Drug Delivery of Magnetic Nano-Particle in the Specific Lung Region. Computation 2020, 8, 10. https://doi.org/10.3390/computation8010010

AMA Style

Ghosh A, Islam MS, Saha SC. Targeted Drug Delivery of Magnetic Nano-Particle in the Specific Lung Region. Computation. 2020; 8(1):10. https://doi.org/10.3390/computation8010010

Chicago/Turabian Style

Ghosh, Anusmriti, Mohammad S. Islam, and Suvash C. Saha 2020. "Targeted Drug Delivery of Magnetic Nano-Particle in the Specific Lung Region" Computation 8, no. 1: 10. https://doi.org/10.3390/computation8010010

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop