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Open AccessArticle

Consideration of Migraines Among Risk Factors for Postoperative Nausea and Vomiting

by Jong-Ho Kim 1,2,†, Man-sup Lim 3,†, Sang-Hwa Lee 4, Young-Suk Kwon 1,2, Jae Jun Lee 1,2 and Jong-Hee Sohn 2,4,*
1
Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, Hallym University college of Medicine, Chuncheon 24253, Korea
2
Institute of New Frontier Research, College of Medicine, Hallym University, Chuncheon 24253, Korea
3
Department of Medical Education, College of Medicine, Hallym University, Chuncheon 24253, Korea
4
Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, Korea
*
Author to whom correspondence should be addressed.
First authors contributed equally to this work.
J. Clin. Med. 2020, 9(10), 3154; https://doi.org/10.3390/jcm9103154
Received: 5 August 2020 / Revised: 22 September 2020 / Accepted: 28 September 2020 / Published: 29 September 2020
(This article belongs to the Section Otolaryngology)
The impact of migraine on postoperative nausea and vomiting (PONV) is controversial, and few studies have focused on their relationship. Thus, we investigated the impact of migraine, among other risk factors, on PONV in a large retrospective study. We analyzed 10 years of clinical data from the Smart Clinical Data Warehouse of Hallym University Medical Center. PONV was defined as nausea or vomiting within the first 24 h after surgery. Patients diagnosed by a neurologist and with a history of triptan use before surgery were enrolled into the migraine group. We enrolled 208,029 patients aged > 18 years who underwent general anesthesia (GA), among whom 19,786 developed PONV within 24 h after GA and 1982 had migraine. Before propensity score matching, the unadjusted and fully adjusted odds ratios (ORs) for PONV in subjects with versus without migraine were 1.52 (95% confidence interval (CI), 1.34–1.72; p < 0.001) and 1.37 (95% CI, 1.21–1.56; p < 0.001), respectively. The OR for PONV in patients with migraine was also high (OR, 1.37; 95% CI, 1.13–1.66; p = 0.001) after matching. Our findings suggest that migraine is a significant risk factor for PONV. View Full-Text
Keywords: postoperative nausea and vomiting; migraine; general anesthesia postoperative nausea and vomiting; migraine; general anesthesia
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MDPI and ACS Style

Kim, J.-H.; Lim, M.-S.; Lee, S.-H.; Kwon, Y.-S.; Lee, J.J.; Sohn, J.-H. Consideration of Migraines Among Risk Factors for Postoperative Nausea and Vomiting. J. Clin. Med. 2020, 9, 3154.

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