Round 1

Reviewer 1 Report

All comments were adequately addressed.

Author Response

Reviewer 1

(Comment) All comments were adequately addressed.

(Response) Thank you very much.

Author Response File: Author Response.docx

Reviewer 2 Report

No further comments.

Author Response

Reviewer 2

(Comment) No further comments.

(Response) Thank you very much.

Reviewer 3 Report

In the present study authors aim at evaluating LV geometrical remodeling after TAVR. They show that the improvement in Zva after TAVR is associated with decreased LVMI/LVEDVI. This is and interesting study and despite of some limitations already stated by the authors, it can represent a good start for further evaluation. 

Minor comment: Please indicate the antithrombotic regimen applied in the study population

Author Response

Reviewer 3

(Comment) In the present study authors aim at evaluating LV geometrical remodeling after TAVR. They show that the improvement in Zva after TAVR is associated with decreased LVMI/LVEDVI. This is an interesting study and despite of some limitations already stated by the authors, it can represent a good start for further evaluation.

Minor comment: Please indicate the antithrombotic regimen applied in the study population

 

(Response) Thank you very much. We add the antithrombotic regimen in the study population, as follows.

 

(Line 52) Aspirin was initiated at the timing of TAVR and continued at least one year.

Author Response File: Author Response.docx

This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.

Round 1

Reviewer 1 Report

The focus of this study is to investigate the relationship between improvement in valvuloarterial impedance and change in LV mass index (LVMI) and the ratio of LVMI to LV end-diastolic volume index. This is an interesting study and I only have a few minor issues.

1)     Sex was independently associated with ΔLVMI. The influence of sex should be added to the discussion.

2)     Many of the patients were placed on anti-hypertensive drugs at baseline. Please clarify in the texts if the patients remained on the same treatment at follow-up. If there was changes in pharmaceutical treatments, how was this handled in the analysis?

Reviewer 2 Report

The authors investigated the correlation between valvuloarterial impedance and LV reverse remodelling after TAVR.  The study is well performed  and has a clear message.  The study has limitations being retrospective and single center and this should be mentioned in the limitations section.

In the conclusion Zva should be measured not only after TAVR but obviously also before TAVR. I would suggest to add before to the last sentence.

Reviewer 3 Report

Comments are enclosed in the word file

Comments for author File: Comments.docx