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Article

Effect of Aerobic Exercise Training and Deconditioning on Oxidative Capacity and Muscle Mitochondrial Enzyme Machinery in Young and Elderly Individuals

1
Department of Neurology, Copenhagen Neuromuscular Center, Rigshospitalet, DK-2100 Copenhagen, Denmark
2
Molecular Physiology Group, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, DK-2100 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(10), 3113; https://doi.org/10.3390/jcm9103113
Received: 31 August 2020 / Revised: 21 September 2020 / Accepted: 23 September 2020 / Published: 26 September 2020
(This article belongs to the Special Issue Prevention and Treatment of Sarcopenia)
Mitochondrial dysfunction is thought to be involved in age-related loss of muscle mass and function (sarcopenia). Since the degree of physical activity is vital for skeletal muscle mitochondrial function and content, the aim of this study was to investigate the effect of 6 weeks of aerobic exercise training and 8 weeks of deconditioning on functional parameters of aerobic capacity and markers of muscle mitochondrial function in elderly compared to young individuals. In 11 healthy, elderly (80 ± 4 years old) and 10 healthy, young (24 ± 3 years old) volunteers, aerobic training improved maximal oxygen consumption rate by 13%, maximal workload by 34%, endurance capacity by 2.4-fold and exercise economy by 12% in the elderly to the same extent as in young individuals. This evidence was accompanied by a similar training-induced increase in muscle citrate synthase (CS) (31%) and mitochondrial complex I–IV activities (51–163%) in elderly and young individuals. After 8 weeks of deconditioning, endurance capacity (−20%), and enzyme activity of CS (−18%) and complex I (−40%), III (−25%), and IV (−26%) decreased in the elderly to a larger extent than in young individuals. In conclusion, we found that elderly have a physiological normal ability to improve aerobic capacity and mitochondrial function with aerobic training compared to young individuals, but had a faster decline in endurance performance and muscle mitochondrial enzyme activity after deconditioning, suggesting an age-related issue in maintaining oxidative metabolism. View Full-Text
Keywords: aerobic exercise training; mitochondria; sarcopenia; endurance; deconditioning; skeletal muscle; elderly aerobic exercise training; mitochondria; sarcopenia; endurance; deconditioning; skeletal muscle; elderly
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MDPI and ACS Style

Fritzen, A.M.; Andersen, S.P.; Qadri, K.A.N.; Thøgersen, F.D.; Krag, T.; Ørngreen, M.C.; Vissing, J.; Jeppesen, T.D. Effect of Aerobic Exercise Training and Deconditioning on Oxidative Capacity and Muscle Mitochondrial Enzyme Machinery in Young and Elderly Individuals. J. Clin. Med. 2020, 9, 3113. https://doi.org/10.3390/jcm9103113

AMA Style

Fritzen AM, Andersen SP, Qadri KAN, Thøgersen FD, Krag T, Ørngreen MC, Vissing J, Jeppesen TD. Effect of Aerobic Exercise Training and Deconditioning on Oxidative Capacity and Muscle Mitochondrial Enzyme Machinery in Young and Elderly Individuals. Journal of Clinical Medicine. 2020; 9(10):3113. https://doi.org/10.3390/jcm9103113

Chicago/Turabian Style

Fritzen, Andreas M., Søren P. Andersen, Khaled A.N. Qadri, Frank D. Thøgersen, Thomas Krag, Mette C. Ørngreen, John Vissing, and Tina D. Jeppesen 2020. "Effect of Aerobic Exercise Training and Deconditioning on Oxidative Capacity and Muscle Mitochondrial Enzyme Machinery in Young and Elderly Individuals" Journal of Clinical Medicine 9, no. 10: 3113. https://doi.org/10.3390/jcm9103113

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