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Article

Low Alanine Aminotransferase Cut-Off for Predicting Liver Outcomes; A Nationwide Population-Based Longitudinal Cohort Study

by 1,†, 2,†, 1,*,‡, 2,*,‡, 3 and 3
1
Department Internal Medicine, Hanyang University, Seoul 133-792, Korea
2
Department of Fusion Data Analytics, School of Industrial Management Engineering, Korea University, Seoul 136-701, Korea
3
Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA 94305, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
J. Clin. Med. 2019, 8(9), 1445; https://doi.org/10.3390/jcm8091445
Received: 6 August 2019 / Revised: 29 August 2019 / Accepted: 9 September 2019 / Published: 11 September 2019
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Background and aim: Recent practice guidelines suggest healthy normal alanine aminotransferase (ALT) levels should be less than 30 U/L for males and 19 U/L for females. We tried to validate the prediction power of the “low cut off” for liver related outcomes in the general population. Methods: A total of 426,013 subjects were followed up for 10 years using the National Health Screening Cohort database. Prediction ability of long term mortality and liver related outcomes between conventional (<40 U/L in men and women) and low (<30 U/L in men and <19 U/L in women) ALT cut-off values were compared. Results: Both conventional and low ALT cut-offs predicted liver related unfavorable outcomes in Kaplan-Meier analysis. Following adjustment for age, body mass index, smoking, exercise, alcohol consumption, fasting blood glucose, and cholesterol via multivariate Cox regression, abnormal ALT using new ‘low ALT cut off’ was a significant independent predictor for liver-related mortality, HCC, and decompensated liver events. When the low cut-off criteria were added to the prediction model, the ability to predetect liver-related hard outcomes significantly increased in both men and women (p-values < 0.0001). The C-index values for predicting liver-related adverse events were the same in both ALT cut-offs, after adjusting confounding factors (C index value: 0.73~0.88). Conclusions: New low ALT cut-off showed good prediction power for liver related unfavorable outcomes. View Full-Text
Keywords: alanine aminotransferase; mortality; upper limit of normal; liver function tests alanine aminotransferase; mortality; upper limit of normal; liver function tests
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MDPI and ACS Style

Park, J.H.; Choi, J.; Jun, D.W.; Han, S.W.; Yeo, Y.H.; Nguyen, M.H. Low Alanine Aminotransferase Cut-Off for Predicting Liver Outcomes; A Nationwide Population-Based Longitudinal Cohort Study. J. Clin. Med. 2019, 8, 1445. https://doi.org/10.3390/jcm8091445

AMA Style

Park JH, Choi J, Jun DW, Han SW, Yeo YH, Nguyen MH. Low Alanine Aminotransferase Cut-Off for Predicting Liver Outcomes; A Nationwide Population-Based Longitudinal Cohort Study. Journal of Clinical Medicine. 2019; 8(9):1445. https://doi.org/10.3390/jcm8091445

Chicago/Turabian Style

Park, Jin H.; Choi, Jun; Jun, Dae W.; Han, Sung W.; Yeo, Yee H.; Nguyen, Mindie H. 2019. "Low Alanine Aminotransferase Cut-Off for Predicting Liver Outcomes; A Nationwide Population-Based Longitudinal Cohort Study" J. Clin. Med. 8, no. 9: 1445. https://doi.org/10.3390/jcm8091445

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