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Article

Associations of Health-Related Quality of Life, Fear of Falling and Objective Measures of Physical Function with Bone Health in Postmenopausal Women with Low Bone Mass

1
Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria 3168, Australia
2
Musculoskeletal Unit, Galgo Medical, 08036 Barcelona, Spain
3
Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria 3168, Australia
4
Department of Medicine and Australian Institute of Musculoskeletal Science, Melbourne Medical School-Western Campus, The University of Melbourne, St Albans, Victoria 3010, Australia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(9), 1370; https://doi.org/10.3390/jcm8091370
Received: 7 August 2019 / Revised: 29 August 2019 / Accepted: 30 August 2019 / Published: 2 September 2019
(This article belongs to the Section Epidemiology & Public Health)
Health-related quality of life (HRQoL) and physical function deteriorate with age and may adversely impact bone health in older adults. We determined associations of objective measures of physical function and HRQoL with bone health in postmenopausal women with low areal bone mineral density (aBMD). Fifty postmenopausal women (64.4 ± 7.7 years old, mean ± standard deviation) with low spine, hip or femoral neck aBMD (T- or Z-score < −1.0) on dual-energy X-ray absorptiometry (DXA) participated. Femoral surface BMD, trabecular, integral and cortical volumetric BMD (vBMD) measurements were obtained using 3D-SHAPER software on DXA. Distal tibial vBMD and microarchitecture were assessed using high-resolution peripheral quantitative computed tomography (HRpQCT). Participants completed self-administered EuroQol-5D (EQ-5D) and modified falls efficacy scale (MFES) questionnaires, and physical function assessments. Stair climb power was positively associated with bone parameters at the hip, femoral neck, and distal tibia (all p < 0.05) in multivariable linear regression. EQ-5D demonstrated no significant associations with bone parameters and MFES was positively associated only with distal tibial cortical vBMD and cortical von Mises stress (both p < 0.05). Objective measures of physical function, particularly muscle power, are more consistently associated with bone parameters compared with self-administered HRQoL questionnaires. View Full-Text
Keywords: osteoporosis; postmenopausal women; physical function; bone; health-related quality of life osteoporosis; postmenopausal women; physical function; bone; health-related quality of life
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MDPI and ACS Style

Gandham, A.; McMillan, L.B.; Ng, C.-A.; Humbert, L.; Bonham, M.P.; Zengin, A.; Ebeling, P.R.; Scott, D. Associations of Health-Related Quality of Life, Fear of Falling and Objective Measures of Physical Function with Bone Health in Postmenopausal Women with Low Bone Mass. J. Clin. Med. 2019, 8, 1370. https://doi.org/10.3390/jcm8091370

AMA Style

Gandham A, McMillan LB, Ng C-A, Humbert L, Bonham MP, Zengin A, Ebeling PR, Scott D. Associations of Health-Related Quality of Life, Fear of Falling and Objective Measures of Physical Function with Bone Health in Postmenopausal Women with Low Bone Mass. Journal of Clinical Medicine. 2019; 8(9):1370. https://doi.org/10.3390/jcm8091370

Chicago/Turabian Style

Gandham, Anoohya, Lachlan B. McMillan, Carrie-Anne Ng, Ludovic Humbert, Maxine P. Bonham, Ayse Zengin, Peter R. Ebeling, and David Scott. 2019. "Associations of Health-Related Quality of Life, Fear of Falling and Objective Measures of Physical Function with Bone Health in Postmenopausal Women with Low Bone Mass" Journal of Clinical Medicine 8, no. 9: 1370. https://doi.org/10.3390/jcm8091370

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