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Article

Long Non-Coding RNAs Modulate Sjögren’s Syndrome Associated Gene Expression and Are Involved in the Pathogenesis of the Disease

1
Department of Medicine, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy
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Sections of Rheumatology, Villa S. Giuseppe, Como and Casa di Cura di Lecco, 23900 Lecco, Italy
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U.O.C. Day Hospital Reumatologia, ASST G. Pini-CTO, 20122 Milan, Italy
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Department of Experimental Medicine, Section of Histology, University of Genova, Via G.B. Marsano 10, 16132 Genova, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(9), 1349; https://doi.org/10.3390/jcm8091349
Received: 31 July 2019 / Revised: 22 August 2019 / Accepted: 27 August 2019 / Published: 1 September 2019
(This article belongs to the Section Immunology)
Primary Sjögren’s syndrome (pSjS) is a chronic systemic autoimmune disorder, primarily affecting exocrine glands; its pathogenesis is still unclear. Long non-coding RNAs (lncRNAs) are thought to play a role in the pathogenesis of autoimmune diseases and a comprehensive analysis of lncRNAs expression in pSjS is still lacking. To this aim, the expression of more than 540,000 human transcripts, including those ascribed to more than 50,000 lncRNAs is profiled at the same time, in a cohort of 16 peripheral blood mononuclear cells PBMCs samples (eight pSjS and eight healthy subjects). A complex network analysis is carried out on the global set of molecular interactions among modulated genes and lncRNAs, leading to the identification of reliable lncRNA-miRNA-gene functional interactions. Taking this approach, a few lncRNAs are identified as targeting highly connected genes in the pSjS transcriptome, since they have a major impact on gene modulation in the disease. Such genes are involved in biological processes and molecular pathways crucial in the pathogenesis of pSjS, including immune response, B cell development and function, inflammation, apoptosis, type I and gamma interferon, epithelial cell adhesion and polarization. The identification of deregulated lncRNAs that modulate genes involved in the typical features of the disease provides insight in disease pathogenesis and opens avenues for the design of novel therapeutic strategies. View Full-Text
Keywords: primary Sjögren’s syndrome; long non-coding RNA; signaling pathway; protein–protein (PPI) network; gene module primary Sjögren’s syndrome; long non-coding RNA; signaling pathway; protein–protein (PPI) network; gene module
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MDPI and ACS Style

Dolcino, M.; Tinazzi, E.; Vitali, C.; Papa, N.D.; Puccetti, A.; Lunardi, C. Long Non-Coding RNAs Modulate Sjögren’s Syndrome Associated Gene Expression and Are Involved in the Pathogenesis of the Disease. J. Clin. Med. 2019, 8, 1349. https://doi.org/10.3390/jcm8091349

AMA Style

Dolcino M, Tinazzi E, Vitali C, Papa ND, Puccetti A, Lunardi C. Long Non-Coding RNAs Modulate Sjögren’s Syndrome Associated Gene Expression and Are Involved in the Pathogenesis of the Disease. Journal of Clinical Medicine. 2019; 8(9):1349. https://doi.org/10.3390/jcm8091349

Chicago/Turabian Style

Dolcino, Marzia, Elisa Tinazzi, Claudio Vitali, Nicoletta Del Papa, Antonio Puccetti, and Claudio Lunardi. 2019. "Long Non-Coding RNAs Modulate Sjögren’s Syndrome Associated Gene Expression and Are Involved in the Pathogenesis of the Disease" Journal of Clinical Medicine 8, no. 9: 1349. https://doi.org/10.3390/jcm8091349

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