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Open AccessArticle

Is Hyperuricemia, an Early-Onset Metabolic Disorder, Causally Associated with Cardiovascular Disease Events in Han Chinese?

1
Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan
2
Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan
3
Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 10055, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Clin. Med. 2019, 8(8), 1202; https://doi.org/10.3390/jcm8081202
Received: 26 June 2019 / Revised: 2 August 2019 / Accepted: 8 August 2019 / Published: 12 August 2019
(This article belongs to the Section Vascular Medicine)
Background: Serum uric acid (SUA) has gradually been recognized as a potential risk factor for cardiovascular disease (CVD). However, whether the relationship is causal remains controversial. Methods: We employed two methods to demonstrate the importance of SUA in CVD development. First, we examined the onset sequence of hyperuricemia in relation to five cardiometabolic (CM) diseases. Second, we conducted a Mendelian randomization (MR) study to causally infer the relationship between SUA and CVD. The information collected from the Cardiovascular Disease Risk Factors Two-Township Study (CVDFACTS) and Taiwan Biobank was used, respectively. Results: The onset sequence study showed that hyperuricemia and hypo-alpha-lipoproteinemia (low HDL-C) have earlier ages of onset than other CM diseases. For the MR analysis, the high weighted genetic risk score (WGRS) group had a significantly increased cumulative lifetime risk of CVD compared with the low WGRS group (OR = 1.62, (1.17−2.23), P = 0.003). Sensitivity analysis using the WGRS derived from other populations’ SUA-influential SNPs revealed similar results. Conclusions: We showed that hyperuricemia is an earlier-onset metabolic disorder than hypertension, hypertriglyceridemia, and diabetes mellitus, indicating that high SUA plays an upstream role in CM development. Moreover, our MR study results support the idea that hyperuricemia may play a causal role in CVD development. Further validation studies in more populations are needed. View Full-Text
Keywords: Onset sequence study; GWAS; Mendelian randomization; serum uric acid; Cardiometabolic disease; Taiwan Biobank; CVDFACTS Onset sequence study; GWAS; Mendelian randomization; serum uric acid; Cardiometabolic disease; Taiwan Biobank; CVDFACTS
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MDPI and ACS Style

Chiang, K.-M.; Tsay, Y.-C.; Vincent Ng, T.-C.; Yang, H.-C.; Huang, Y.-T.; Chen, C.-H.; Pan, W.-H. Is Hyperuricemia, an Early-Onset Metabolic Disorder, Causally Associated with Cardiovascular Disease Events in Han Chinese? J. Clin. Med. 2019, 8, 1202. https://doi.org/10.3390/jcm8081202

AMA Style

Chiang K-M, Tsay Y-C, Vincent Ng T-C, Yang H-C, Huang Y-T, Chen C-H, Pan W-H. Is Hyperuricemia, an Early-Onset Metabolic Disorder, Causally Associated with Cardiovascular Disease Events in Han Chinese? Journal of Clinical Medicine. 2019; 8(8):1202. https://doi.org/10.3390/jcm8081202

Chicago/Turabian Style

Chiang, Kuang-Mao; Tsay, Yuh-Chyuan; Vincent Ng, Ta-Chou; Yang, Hsin-Chou; Huang, Yen-Tsung; Chen, Chen-Hsin; Pan, Wen-Harn. 2019. "Is Hyperuricemia, an Early-Onset Metabolic Disorder, Causally Associated with Cardiovascular Disease Events in Han Chinese?" J. Clin. Med. 8, no. 8: 1202. https://doi.org/10.3390/jcm8081202

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