Decreased Level of Blood MicroRNA-133b in Men with Opioid Use Disorder on Methadone Maintenance Therapy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients and Controls
2.2. Laboratory Data
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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OUD (N = 50, male) | Controls (N = 25, male) | p | Adjusted p a | |
---|---|---|---|---|
Age (years) | 44.76 ± 6.18 | 46.32 ± 6.16 | 0.305 | 0.720 |
BMI (kg/m2) | 24.92 ± 3.55 | 24.65 ± 3.23 | 0.748 | 0.866 |
Onset age (years) | 25.54 ± 6.03 | NA | ||
Duration of MMT (years) | 3.96 ± 3.33 | NA | ||
Methadone dosage in the past one month (mg/day) | 65.00 ± 26.28 | NA | ||
miR-133b | 0.78 ± 0.87 | 1.20 ± 0.75 | 0.041 * | 0.328 |
miR-23b | 0.97 ± 1.89 | 1.72 ± 2.28 | 0.133 | 0.532 |
miR-190 | 1.33 ± 1.45 | 1.40 ± 1.19 | 0.829 | 0.866 |
miR-206 | 2.57 ± 9.68 | 1.29 ± 0.95 | 0.360 | 0.720 |
miR-210 | 1.32 ± 0.85 | 1.26 ± 0.92 | 0.792 | 0.866 |
miR-21 | 1.05 ± 0.48 | 1.07 ± 0.36 | 0.866 | 0.866 |
Onset Age | p | Duration of MMT | p | Methadone Dosage | p | |
---|---|---|---|---|---|---|
miR-133b | 0.17 (−0.12, 0.42) | 0.249 | −0.18 (−0.44, 0.10) | 0.201 | −0.27 (−0.51, 0.01) | 0.055 |
miR-23b | −0.16 (−0.42, 0.12) | 0.256 | 0.17 (−0.11, 0.43) | 0.240 | −0.08 (−0.35, 0.21) | 0.594 |
miR-190 | 0.25 (−0.03, 0.50) | 0.074 | 0.02 (−0.26, 0.30) | 0.897 | −0.01 (−0.29, 0.27) | 0.955 |
miR-206 | −0.11 (−0.38, 0.17) | 0.431 | −0.10 (−0.36, 0.19) | 0.511 | −0.17 (−0.42, 0.12) | 0.249 |
miR-210 | −0.14 (−0.41, 0.14) | 0.322 | −0.26 (−0.50, 0.02) | 0.065 | 0.04 (−0.24, 0.31) | 0.793 |
miR-21 | 0.03 (−0.25, 0.31) | 0.818 | −0.18 (−0.44, 0.10) | 0.213 | −0.18 (−0.44, 0.11) | 0.216 |
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Hsu, C.-W.; Huang, T.-L.; Tsai, M.-C. Decreased Level of Blood MicroRNA-133b in Men with Opioid Use Disorder on Methadone Maintenance Therapy. J. Clin. Med. 2019, 8, 1105. https://doi.org/10.3390/jcm8081105
Hsu C-W, Huang T-L, Tsai M-C. Decreased Level of Blood MicroRNA-133b in Men with Opioid Use Disorder on Methadone Maintenance Therapy. Journal of Clinical Medicine. 2019; 8(8):1105. https://doi.org/10.3390/jcm8081105
Chicago/Turabian StyleHsu, Chih-Wei, Tiao-Lai Huang, and Meng-Chang Tsai. 2019. "Decreased Level of Blood MicroRNA-133b in Men with Opioid Use Disorder on Methadone Maintenance Therapy" Journal of Clinical Medicine 8, no. 8: 1105. https://doi.org/10.3390/jcm8081105