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Article

Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study

1
Department of Family Medicine, Hanyang University College of Medicine, Seoul 04763, Korea
2
Department of Family Medicine, Korea University College of Medicine, Seoul 02841, Korea
3
Department of Biostatistics, the Catholic University of Korea College of Medicine, Seoul 06591, Korea
4
Department of Medical Statistics, the Catholic University of Korea College of Medicine, Seoul 06591, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Clin. Med. 2019, 8(7), 950; https://doi.org/10.3390/jcm8070950
Received: 31 May 2019 / Revised: 19 June 2019 / Accepted: 26 June 2019 / Published: 30 June 2019
(This article belongs to the Special Issue Type 2 Diabetes: Update on Pathophysiology and Treatment)
We aimed to investigate how body weight fluctuation affects the risk of developing type 2 diabetes by conducting a nationwide cohort study. A total of 3,855,884 participants from the National Health Insurance System health check-up data from 2012 were included in this study, and follow-up continued until 2016. Body weight was measured at least thrice between 2009 and 2012. Body weight variability (BWV) was estimated using average successive variability (ASV) indices. Cox proportional hazards regression models were used to evaluate the association of BWV with the risk of type 2 diabetes using hazard ratios (HRs) and 95% confidence intervals (CIs). Body weight fluctuation was associated with a higher risk of incident diabetes after adjustment for confounders (HR 1.10, 95% CI 1.07, 1.12 in the highest BWV quartile compared to the lowest). Regardless of the weight change status, the highest ASV quartile of BWV increased the risk for diabetes. Even subjects with a normal glucose tolerance status and those aged under 65 years had a higher risk of diabetes if their body weight highly fluctuated during the follow-up years. Our results suggest that body weight variability is an independent risk factor for diabetes. It is important to pay attention to frequent body weight fluctuations. View Full-Text
Keywords: average successive variability; body weight fluctuation; cohort study; weight change; type 2 diabetes average successive variability; body weight fluctuation; cohort study; weight change; type 2 diabetes
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MDPI and ACS Style

Park, K.-Y.; Hwang, H.-S.; Cho, K.-H.; Han, K.; Nam, G.E.; Kim, Y.H.; Kwon, Y.; Park, Y.-G. Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study. J. Clin. Med. 2019, 8, 950. https://doi.org/10.3390/jcm8070950

AMA Style

Park K-Y, Hwang H-S, Cho K-H, Han K, Nam GE, Kim YH, Kwon Y, Park Y-G. Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study. Journal of Clinical Medicine. 2019; 8(7):950. https://doi.org/10.3390/jcm8070950

Chicago/Turabian Style

Park, Kye-Yeung, Hwan-Sik Hwang, Kyung-Hwan Cho, Kyungdo Han, Ga Eun Nam, Yang Hyun Kim, Yeongkeun Kwon, and Yong-Gyu Park. 2019. "Body Weight Fluctuation as a Risk Factor for Type 2 Diabetes: Results from a Nationwide Cohort Study" Journal of Clinical Medicine 8, no. 7: 950. https://doi.org/10.3390/jcm8070950

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