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Invasive Validation of Antares, a New Algorithm to Calculate Central Blood Pressure from Oscillometric Upper Arm Pulse Waves

Department of Internal Medicine B, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, D-17475 Greifswald, Germany
German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, D-17475 Greifswald, Germany
Zentralklinik Bad Berka GmbH, Herzzentrum, Department of Cardiology, Robert-Koch-Allee 9, D-99437 Bad Berka, Germany
Klinik für Allgemeine und Interventionelle Kardiologie/Angiologie, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, D-32545 Bad Oeynhausen, Germany
EPC—European Prevention Center, Luise-Rainer-Straße 6-10, D-40235 Düsseldorf, Germany
Department of Medical Psychology and Psychotherapy, Medical University of Graz, Auenbruggerplatz 2/8, A-8036 Graz, Austria
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(7), 1073;
Received: 20 June 2019 / Revised: 13 July 2019 / Accepted: 18 July 2019 / Published: 22 July 2019
(This article belongs to the Section Vascular Medicine)
Background: Antares is an algorithm for pulse wave analysis (PWA) by oscillometric blood pressure (BP) monitors in order to estimate central (aortic) blood pressure (cBP). Antares aims to enable brachial cuff-based BP monitors to be type II-devices, determining absolute cBP values independently of potential peripheral BP inaccuracies. The present study is an invasive validation of the Antares algorithm in the custo screen 400. Methods: We followed entirely the 2017 ARTERY protocol for validation of non-invasive cBP devices, the 2013 American National Standards Institute, Inc./Association for the Advancement of Medical Instrumentation/International Organization for Standardization (ANSI/AAMI/ISO) 81060-2 and 2018 AAMI/European Society of Hypertension (ESH)/ISO validation standard protocols. In total, 191 patients undergoing cardiac catheterization were included, of which 145 patients entered analysis. Invasive cBP recordings were compared to simultaneous non-invasive cBP estimations using the Antares algorithm, integrated into an oscillometric BP monitor. Results: Mean difference between invasive and non-invasively estimated systolic cBP was 0.71 mmHg with standard deviation of 5.95 mmHg, fulfilling highest validation criteria. Conclusion: Antares is the first algorithm for estimation of cBP that entirely fulfills the 2017 ARTERY and AAMI/ESH/ISO validation protocols. The Antares algorithm turns the custo screen 400 BP monitor into a type II-device. Integration of Antares into commercially available BP monitors could make it possible to measure PWA parameters in virtually every practice in future. View Full-Text
Keywords: validation; invasive; central blood pressure; pulse wave analysis; antares validation; invasive; central blood pressure; pulse wave analysis; antares
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Dörr, M.; Richter, S.; Eckert, S.; Ohlow, M.-A.; Hammer, F.; Hummel, A.; Dornberger, V.; Genzel, E.; Baulmann, J. Invasive Validation of Antares, a New Algorithm to Calculate Central Blood Pressure from Oscillometric Upper Arm Pulse Waves. J. Clin. Med. 2019, 8, 1073.

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