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Diabetic Retinopathy, lncRNAs, and Inflammation: A Dynamic, Interconnected Network

1
Department of Pathology and Laboratory Medicine, Western University, London, ON N6A5A5, Canada
2
Department of Optometry and Vision Science, University of Waterloo, Waterloo, ON N2L3G1, Canada
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(7), 1033; https://doi.org/10.3390/jcm8071033
Received: 7 June 2019 / Revised: 3 July 2019 / Accepted: 9 July 2019 / Published: 14 July 2019
(This article belongs to the Special Issue Diabetic Retinopathy: Biomolecules and Pathophysiology)
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Abstract

Diabetic retinopathy (DR) is reaching epidemic levels globally due to the increase in prevalence of diabetes mellitus (DM). DR also has detrimental effects to quality of life, as it is the leading cause of blindness in the working-age population and the most common cause of vision loss in individuals with DM. Over several decades, many studies have recognized the role of inflammation in the development and progression of DR; however, in recent years, accumulating evidence has also suggested that non-coding RNAs, especially long non-coding (lncRNAs), are aberrantly expressed in diabetes and may play a putative role in the development and progression of DR through the modulation of gene expression at the transcriptional, post-transcriptional, or epigenetic level. In this review, we will first highlight some of the key inflammatory mediators and transcription factors involved in DR, and we will then introduce the critical roles of lncRNAs in DR and inflammation. Following this, we will discuss the implications of lncRNAs in other epigenetic mechanisms that may also contribute to the progression of inflammation in DR. View Full-Text
Keywords: diabetic retinopathy; inflammation; lncRNAs; epigenetics; histone modifications; DNA methylation; miRNAs diabetic retinopathy; inflammation; lncRNAs; epigenetics; histone modifications; DNA methylation; miRNAs
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Biswas, S.; Sarabusky, M.; Chakrabarti, S. Diabetic Retinopathy, lncRNAs, and Inflammation: A Dynamic, Interconnected Network. J. Clin. Med. 2019, 8, 1033.

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