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Mismatch Repair/Microsatellite Instability Testing Practices among US Physicians Treating Patients with Advanced/Metastatic Colorectal Cancer

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Merck & Co., Inc., North Wales, PA 19454, USA
ICON plc, London W12 0BZ, UK
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Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(4), 558;
Received: 18 March 2019 / Revised: 16 April 2019 / Accepted: 19 April 2019 / Published: 24 April 2019
(This article belongs to the Section Oncology)
PDF [669 KB, uploaded 26 April 2019]


The study objective was to assess US physicians’ Mismatch Repair/Microsatellite Instability (MMR/MSI) testing practices for metastatic colorectal cancer (mCRC) patients. A non-interventional, cross-sectional online survey was conducted among 151 physicians (91 oncologists, 15 surgeons and 45 pathologists) treating mCRC patients in the US. Eligible physicians were US-based with at least 5 years of experience treating CRC patients, had at least one mCRC patient in their routine care in the past 6 months, and had ordered at least one MMR/MSI test for CRC in the past 6 months. Descriptive and logistic regression analyses were performed. Awareness of specific MMR/MSI testing guidelines was high (n = 127, 84.1%). Of those, 93.7% (119/127) physicians had awareness of specific published guidelines with majority 67.2% (80/119) being aware of National Comprehensive Cancer Network (NCCN) guidelines. Universal testing for all CRC patients was performed by 68.9% (104/151) physicians, while 29.8% (45/151) selectively order the test for some CRC patients. Key barriers for testing included insufficient tissue sample (48.3%, 73/151), patient declined to have the test done (35.8%, 54/151) and insurance cost concerns for patients (31.1%, 47/151), while 27.2% (41/151) reported no barriers. The survey demonstrated high awareness and compliance with MMR/MSI testing guidelines although universal testing rates seem to be suboptimal. View Full-Text
Keywords: colorectal cancer; survey; mismatch repair/microsatellite instability testing colorectal cancer; survey; mismatch repair/microsatellite instability testing

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Eriksson, J.; Amonkar, M.; Al-Jassar, G.; Lambert, J.; Malmenäs, M.; Chase, M.; Sun, L.; Kollmar, L.; Vichnin, M. Mismatch Repair/Microsatellite Instability Testing Practices among US Physicians Treating Patients with Advanced/Metastatic Colorectal Cancer. J. Clin. Med. 2019, 8, 558.

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