Vasculogenic Chronic Ulcer: Tissue Regeneration with an Innovative Dermal Substitute
AbstractThe healing of venous and arterial ulcers is slow, and in some cases, they may not heal at all. This study aims to demonstrate the clinical advantage of Nevelia®, an innovative collagen dermal template substitute (DS) in venous and arterial chronic ulcers treatment. 35 patients affected by chronic vascular ulcers with a mean area of 35.1 ± 31.8 cm2 were treated with DS followed by autologous dermal epidermal graft (DEG). Follow-up was performed at 7-14-21 and 28 days after DS implant and 7-14-21 and 28 days after DEG. At 28 days after DEG, the mean values of Manchester Scar Scale was of 1.8 ± 0.7 for skin color, 1.6 ± 0.7 for skin contour, 1.7 ± 0.7 for distortion, and 1.7 ± 0.7 for skin texture, whereas skin was matte in 27 patients (77%) and shiny in the remaining eight cases (23%). Histological findings correlate with the clinical result showing a regenerated skin with reactive epidermal hyperplasia and dermal granulation tissue after two weeks (T1), and after three weeks (T2) a re-epithelialization and a formed new tissue architecture analogue to normal skin physiology. These data suggest that Nevelia® could be useful to treat chronic venous and arterial ulcers. View Full-Text
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De Angelis, B.; Orlandi, F.; Morais D’Autilio, M.F.L.; Di Segni, C.; Scioli, M.G.; Orlandi, A.; Cervelli, V.; Gentile, P. Vasculogenic Chronic Ulcer: Tissue Regeneration with an Innovative Dermal Substitute. J. Clin. Med. 2019, 8, 525.
De Angelis B, Orlandi F, Morais D’Autilio MFL, Di Segni C, Scioli MG, Orlandi A, Cervelli V, Gentile P. Vasculogenic Chronic Ulcer: Tissue Regeneration with an Innovative Dermal Substitute. Journal of Clinical Medicine. 2019; 8(4):525.Chicago/Turabian Style
De Angelis, Barbara; Orlandi, Fabrizio; Morais D’Autilio, Margarida F.L.; Di Segni, Chiara; Scioli, Maria G.; Orlandi, Augusto; Cervelli, Valerio; Gentile, Pietro. 2019. "Vasculogenic Chronic Ulcer: Tissue Regeneration with an Innovative Dermal Substitute." J. Clin. Med. 8, no. 4: 525.
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