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Vasculogenic Chronic Ulcer: Tissue Regeneration with an Innovative Dermal Substitute

Department of Surgical Science, Plastic and Reconstructive Surgery Unit, University of Rome Tor Vergata, 00133 Rome, Italy
Department of Biomedicine and Prevention, Pathologic Anatomy Institute, University of Rome “Tor Vergata”, 00133 Rome, Italy
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(4), 525;
Received: 16 March 2019 / Revised: 8 April 2019 / Accepted: 15 April 2019 / Published: 17 April 2019
(This article belongs to the Section Vascular Medicine)
PDF [2428 KB, uploaded 17 April 2019]


The healing of venous and arterial ulcers is slow, and in some cases, they may not heal at all. This study aims to demonstrate the clinical advantage of Nevelia®, an innovative collagen dermal template substitute (DS) in venous and arterial chronic ulcers treatment. 35 patients affected by chronic vascular ulcers with a mean area of 35.1 ± 31.8 cm2 were treated with DS followed by autologous dermal epidermal graft (DEG). Follow-up was performed at 7-14-21 and 28 days after DS implant and 7-14-21 and 28 days after DEG. At 28 days after DEG, the mean values of Manchester Scar Scale was of 1.8 ± 0.7 for skin color, 1.6 ± 0.7 for skin contour, 1.7 ± 0.7 for distortion, and 1.7 ± 0.7 for skin texture, whereas skin was matte in 27 patients (77%) and shiny in the remaining eight cases (23%). Histological findings correlate with the clinical result showing a regenerated skin with reactive epidermal hyperplasia and dermal granulation tissue after two weeks (T1), and after three weeks (T2) a re-epithelialization and a formed new tissue architecture analogue to normal skin physiology. These data suggest that Nevelia® could be useful to treat chronic venous and arterial ulcers. View Full-Text
Keywords: dermal substitute; Nevelia; chronic ulcers; arterial; venous; collagen dermal substitute; Nevelia; chronic ulcers; arterial; venous; collagen

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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De Angelis, B.; Orlandi, F.; Morais D’Autilio, M.F.L.; Di Segni, C.; Scioli, M.G.; Orlandi, A.; Cervelli, V.; Gentile, P. Vasculogenic Chronic Ulcer: Tissue Regeneration with an Innovative Dermal Substitute. J. Clin. Med. 2019, 8, 525.

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